Test drug to block endothelin for hard-to-control blood pressure
Treatments studied
Part of Heart & circulation clinical trials.
This Phase 2 trial tests whether blocking endothelin (using bosentan and related treatments) can improve blood pressure in people with resistant hypertension—high blood pressure that stays high despite multiple medicines. It may help if your blood pressure is still above target even with the right combination of therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 30 to 80 years old
- Your blood pressure stays high despite 3 blood pressure medicines, including a water pill (diuretic), taken at the right dose
- Your blood pressure is confirmed at home (average at least 135/85) or with 24-hour monitoring (average at least 130/80)
- Your blood count is adequate (hemoglobin at least 12 g/dL)
- You can safely use the study medicines based on pregnancy risk and other medical restrictions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This trial tests a new medication called aprocitentan as an add-on treatment for people whose high blood pressure remains elevated despite taking three or more blood pressure medications. The goal is to see if adding this new drug can lower blood pressure further and be safe to use.
This trial tests a new drug called SAL0140 for people whose high blood pressure is not controlled by current treatments. It may help lower blood pressure when other medications haven't worked well enough.
This trial tests a new medication (HRS-1780) for people whose high blood pressure is not well controlled, even with current treatments. It may help lower blood pressure effectively.
This Phase 1/2 study tests nesiritide, a medicine that affects blood vessels and heart strain, to see if it can improve blood pressure control in people with hypertension. It’s mainly for people whose blood pressure stays high even during the day despite medication.
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