Clinical trials
Resistant Hypertension clinical trials
Below are recruiting resistant hypertension clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06169241RecruitingEarly Phase 1
Nitrate supplement for resistant hypertension
This trial tests whether a natural nitrate supplement (like beetroot juice) can help lower blood pressure and improve blood vessel function in people with resistant hypertension. If you have resistant hypertension and your medications have been stable for at least 30 days, you may be eligible.
Rio de JaneiroAges 18–75 - NCT06526858Recruiting
Laparoscopic kidney nerve treatment for resistant hypertension
This study tests a new treatment called HyperQure RDN, a laparoscopic (keyhole) surgery that targets nerves near the kidneys to lower blood pressure in people with resistant hypertension. If you have tried multiple medications but your blood pressure is still high, this procedure might offer an alternative approach.
Orange, CaliforniaAges 22–80 - NCT06246396RecruitingPhase 4
Minocycline for resistant high blood pressure
This study tests whether minocycline, a common antibiotic, can help lower blood pressure in people whose high blood pressure is not controlled by multiple medications. If you have resistant hypertension, this trial may offer a new option to better manage your condition.
Gainesville, FloridaAges 18–100 - NCT04388124RecruitingPhase 2
Test drug to block endothelin for hard-to-control blood pressure
This Phase 2 trial tests whether blocking endothelin (using bosentan and related treatments) can improve blood pressure in people with resistant hypertension—high blood pressure that stays high despite multiple medicines. It may help if your blood pressure is still above target even with the right combination of therapy.
RouenAges 18–80 - NCT02057783Recruiting
Exercise program to lower blood pressure in sleep apnea
This trial tests whether a supervised physical activity program can help lower blood pressure in people with obstructive sleep apnea and resistant high blood pressure. It may help you control blood pressure when it has not improved despite multiple medications.
QuébecAges 18–80 - NCT07751445Recruiting
Weight training for blood pressure control
This study tests whether exercising one arm or leg at a time versus both together can lower blood pressure better in people with hypertension. It may help you manage your blood pressure through a safe, supervised workout program.
TunceliAges 40–75 - NCT06940011RecruitingPhase 2
Endocalyx for hard-to-treat high blood pressure
This trial tests a new treatment called Endocalyx for people whose high blood pressure doesn't get better with multiple medications. It aims to see if Endocalyx can help lower blood pressure when standard medicines aren't enough.
Amsterdam, North HollandAges 18 years+ - NCT07058922Enrolling by invitationEarly Phase 1
Beetroot powder for resistant hypertension
This study tests if a powdered beetroot supplement can improve blood flow in the small blood vessels of people with resistant hypertension. If you have hard-to-treat high blood pressure, this might be an option for you.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT07259733Recruiting
Fast control of tough high blood pressure in public clinics
This study tests a fast way to get high blood pressure under control faster for people whose current pills aren't working well enough. It focuses on people who have trouble taking all their medicine as directed (like missing doses).
São Paulo, São PauloAges 18–75 - NCT07383220Recruiting
Electrical stimulation and exercise for resistant high blood pressure
This trial tests if adding electrical stimulation to exercise can improve blood flow in people with resistant high blood pressure. It may help those whose blood pressure stays high despite taking multiple medications.
Port Said, Port Said GovernorateAges 50–60 - NCT06450327Recruiting
Resistant Hypertension: A Complex Condition Study
This study looks at why some people with hard-to-control high blood pressure (resistant hypertension) may also have other health problems. It aims to better understand the condition and how to help patients like you.
Votuporanga, São PauloAges 18–85 - NCT06676553RecruitingPhase 4
Optimized kidney nerve treatment for high blood pressure
This trial tests a new way to perform a procedure called renal denervation, which uses radio waves to calm overactive kidney nerves that can raise blood pressure. By getting feedback during the procedure, doctors hope to make the treatment more effective for people with high blood pressure.
TaipeiAges 18 years+ - NCT06228677Recruiting
Catecholamine levels during adrenal artery embolization
This trial measures hormone levels in blood during a procedure to treat high blood pressure caused by an adrenal gland problem. It may help doctors understand how the body responds during treatment.
Chengdu, SichuanAges 18 years+ - NCT07483372RecruitingPhase 1
SC101 injection for resistant hypertension with kidney disease
This early-phase trial tests an injection called SC101 into the fat around your kidney. It aims to help lower blood pressure in people whose hypertension is poorly controlled despite multiple medications and who have moderate to severe chronic kidney disease.
Suzhou, JiangsuAges 18–65 - NCT02880631Recruiting
Barostim therapy for resistant hypertension
This trial is evaluating a device called BAROSTIM NEO, which sends electrical signals to help lower high blood pressure. It is for people who have recently had the device implanted and still have high blood pressure despite taking multiple medications.
BerlinAges Any age - NCT06343298RecruitingPhase 2
Study of manp for hard-to-control high blood pressure
This study tests a new investigational drug called MANP to see if it can lower blood pressure in people whose blood pressure stays high even when they are already taking several medications. If it works, this drug might offer a new option for people with difficult-to-control hypertension.
Little Rock, ArkansasAges 18–80 - NCT06510998Recruiting
Handgrip exercise for lowering blood pressure
This trial tests if simple handgrip exercises (a type of isometric resistance exercise) can help lower blood pressure in people with high blood pressure. It compares the exercise group to a control group to see if this easy activity can improve heart health.
Hong KongAges 18 years+ - NCT07356778RecruitingPhase 4
Study of sotatercept for Eisenmenger syndrome patients
This trial tests a new drug called sotatercept for people with Eisenmenger syndrome or a related heart defect that hasn't been repaired. It may help if current treatments aren't working well enough.
Fukuoka, Not Required For This CountryAges 18 years+ - NCT07081243Recruiting
A study on a procedure for hard-to-treat high blood pressure
This study looks at a procedure called renal denervation, which uses a device to calm overactive nerves in the kidneys that can drive high blood pressure. It is for people whose blood pressure stays high even with several medications, or who cannot tolerate blood pressure pills.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT02646475RecruitingPhase 1
Study angiotensin medicine to improve metabolism in obesity
This Phase 1 study tests how a medication that affects the body’s angiotensin system (angiotensin-(1-7)) changes metabolism in adults with obesity, insulin resistance, and high blood pressure. It may help researchers understand whether this approach can improve blood sugar/insulin function and related body changes.
Nashville, TennesseeAges 18–60 - NCT06646601Recruiting
Garden-based program for heart and stroke recovery
This trial tests a preventive program that uses a therapeutic garden to help people with heart or blood vessel conditions. It looks at whether patients find the program helpful and easy to take part in.
GapAges 18 years+ - NCT06556407Recruiting
Kidney nerve treatment for high blood pressure in dialysis patients
This trial tests a procedure called renal denervation (using radio waves to calm overactive nerves in the kidney) to see if it helps lower blood pressure in people on dialysis who have resistant high blood pressure.
Erlangen, BavariaAges 18–99 - NCT06518915Recruiting
Baroloop trial for stubborn high blood pressure
This trial tests a device that helps control blood pressure by gently stimulating a nerve in your neck. It may help if your blood pressure stays high even while taking three different medications.
Münster, North Rhine-WestphaliaAges 18 years+ - NCT07221279Recruiting
Walking study for weight and heart health in adults
This study tests if a specific number of daily steps can help overweight or obese adults improve body composition and reduce heart disease risk. It's for people who are otherwise healthy but may have high blood pressure or joint pain managed by medication.
Kennesaw, GeorgiaAges 20 years+
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Common questions
- Are there clinical trials for resistant hypertension?
- Yes. Clin2 currently lists 29 recruiting resistant hypertension studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a resistant hypertension trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a resistant hypertension trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.