Morphine to prevent early NIV failure in COPD flare-ups
Part of Lungs & breathing clinical trials.
This trial studies whether morphine can help people with a COPD flare-up avoid “non-invasive ventilation” (breathing support through a mask) failing early. The goal is to reduce how often people need escalation of care soon after starting NIV.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older
- You smoke or used to smoke at least 10 “pack-years”
- You have a known COPD history and are having an acute flare-up
- Doctors need to start NIV because your blood gas shows acidemia (pH below 7.35)
- You can use NIV (no major safety reasons you can’t tolerate a mask or need immediate intubation)
- You can give consent (or, in emergencies, consent can be arranged after you’re included)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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