Stem cell transplant for adults with hard-to-treat aplastic anemia
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests a new way of preparing adult patients with hard-to-treat aplastic anemia for a stem cell transplant. It uses a lower-intensity conditioning regimen (TMI) and umbilical cord blood, which may be safer and more effective for patients who have failed other treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be an adult between 18 and 49 years old.
- You must have aplastic anemia that is either severe or non-severe, and it must have not responded to standard treatments or come back after treatment.
- You must not have a matched sibling or unrelated donor available for a standard transplant.
- You need to be in generally good health with a performance status score of 60 or higher (meaning you can do most daily activities with some help).
- You must not have had a prior stem cell transplant or have certain active infections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests a new way to treat severe aplastic anemia by combining a stem cell transplant from a half-matched donor with special stem cells from umbilical cord blood. The goal is to help your body make healthy blood cells again.
This trial studies using a donor's blood stem cells (from bone marrow or blood) for a transplant in people with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal is to see if using a mix of both types of cells is better than just blood cells alone.
This study tests a new combination of drugs to prepare older patients (40–60 years old) with severe aplastic anemia for a stem cell transplant from a half-matched donor. The goal is to make the transplant safer and more effective for this age group.
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