Puberty blockers and estradiol effects on heart health
Part of Hormones & metabolism, Mental health clinical trials.
This study looks at how puberty blockers and then estradiol (estrogen) may affect heart and metabolism health in teens. It may help doctors understand risks and benefits for transgender youth starting gender-affirming hormone care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a transgender girl (assigned male at birth) or a teen who is 13–16 years old
- If you are using a puberty-blocking medicine already, you’ve been on it for more than 6 months
- You plan to start estradiol with a clinician within the next 4 months
- You can understand and complete study tasks (no major cognitive, psychiatric, or physical limits)
- You are not taking antipsychotic medicines
- You do not have certain health conditions, like diabetes, PCOS (if you were assigned female at birth), or high blood pressure
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how puberty suppression (puberty blockers) may affect heart health and metabolism in children who are early in puberty. It may help researchers understand who benefits most and what changes happen during treatment.
This study looks at how cross-sex hormone treatment affects the heart and fat in the liver. It aims to help understand the safety of hormone therapy in transgender individuals.
This study looks at how cross-sex hormone therapy affects appetite (eating behavior), metabolism (how your body uses food), energy balance, and cardiovascular (heart and blood vessel) health. You may be included if you meet specific health and safety requirements and can follow study procedures.
This study looks at how testosterone affects the brain and reproductive hormones in people who are starting testosterone therapy and those who are not. It aims to understand the body's natural hormone cycles.
This study tests whether hormone therapy (such as testosterone or estrogen) helps reduce distress in teenagers who feel their gender does not match their body. It aims to see if starting hormones at this age improves mental well-being and overall quality of life.
This study looks at how people respond early after starting gender-confirming hormones. It may help doctors understand what changes happen soon after treatment starts and how to manage it safely.
Hear when a new Transgenderism trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.