Clin2
NCT04601974Possibly a fitNot yet recruiting

Gene therapy for focal epilepsy

Drug Resistant Epilepsy

Part of Brain & nervous system clinical trials.

This trial tests a gene therapy given directly into the brain to quiet the overactive nerve cells that cause seizures. It's an option for adults with focal epilepsy who are already planning surgery and haven't found relief from medication.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
10 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have focal epilepsy that hasn't been controlled by at least two medications.
  • You are being evaluated for brain surgery to remove the specific area where your seizures start.
  • You are 18 or older and expected to live at least 5 more years.
  • You live within 1 hour of a hospital that can handle emergency brain surgery.
  • You don't have cancer, a vascular brain lesion, active HIV, or untreated psychiatric illness.
  • You agree to use effective birth control during the trial and for 3 months after treatment.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06665880Not yet recruiting
Genes and proteins in hard-to-treat epilepsy patients

This study looks at genes, proteins, and other body chemicals in people with drug-resistant epilepsy (seizures that continue despite trying multiple medications). By studying samples from people who are already having SEEG surgery to find where seizures start, researchers hope to discover new clues about what makes epilepsy hard to treat. The results may help develop better tests or treatments in the future.

Beijing
NCT06334952Recruiting
Personalized brain stimulation for hard-to-treat epilepsy

This study tests a personalized, non-invasive brain stimulation method called tDCS for people with drug-resistant epilepsy that starts in one part of the brain. It aims to reduce seizures in those who cannot have surgery or have not been helped by surgery.

Bordeaux
NCT06063850Recruiting· Phase 1/Phase 2
Gene therapy for adults with hard-to-control epilepsy

This trial tests a one-time gene therapy (AMT-260) for adults whose seizures start in one area of the brain (the temporal lobe) and aren't controlled by medication. The goal is to see if it's safe and reduces seizure frequency.

Birmingham, Alabama
NCT07572812Not yet recruiting· Phase 1
Cell therapy for drug-resistant temporal lobe epilepsy

This trial tests a new cell-based treatment for people with epilepsy that has not improved with standard medications. The treatment aims to reduce seizures in patients with a specific type of epilepsy originating from one side of the brain.

Beijing, Beijing Municipality
NCT06422923Recruiting· Phase 1/Phase 2
Cell therapy for hard-to-treat epilepsy starting in both temporal lobes

This trial tests a new cell therapy (NRTX-1001) for people with epilepsy that starts in both sides of the brain's temporal lobes and doesn't get better with medication. It aims to reduce or stop seizures.

Little Rock, Arkansas
NCT06794606Recruiting
Study for drug-resistant focal epilepsy

This trial looks at ways to diagnose and treat focal epilepsy that isn't controlled by medications. It includes patients with or without a visible brain lesion on imaging.

Milan

Hear when a new Drug Resistant Epilepsy trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.