PEEP breathing support for adults with acute lung failure
Part of Lungs & breathing clinical trials.
This trial studies whether a specific breathing setting called PEEP can help adults whose lungs are failing and who need a breathing machine. Doctors will compare outcomes in patients who fit this critical illness pattern and are safe for the required positioning and ventilator settings.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (over 18 years old).
- You are already on a breathing machine (intubated and on mechanical ventilation) for more than 24 hours.
- Your lung oxygen levels are low despite breathing support (meeting the trial’s oxygen ratio threshold) and you need certain ventilator settings (FiO2 at least 0.30 and PEEP at least 5).
- Your acute lung failure is caused by a problem in the lungs (a pulmonary cause).
- There are no major safety issues that prevent using higher PEEP, such as very severe head or chest trauma.
- You can safely lie flat (supine position), and blood pressure is stable enough that your team does not consider you hemodynamically unstable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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