Lung effects of breathing support in severe respiratory failure
Part of Brain & nervous system, Lungs & breathing clinical trials.
This study looks at how the lungs react when they collapse or overinflate during mechanical ventilation in people with severe acute respiratory distress syndrome (ARDS). It aims to find better ways to adjust breathing support to improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have severe breathing failure that started within the last 7 days, caused by something like pneumonia, infection, trauma, transfusion, aspiration, or shock.
- Your lungs must show signs of fluid or consolidation on an X-ray, CT scan, or ultrasound, not fully explained by other causes.
- You must be on a breathing machine (mechanical ventilator) and have low oxygen levels in your blood, specifically a ratio of oxygen to the amount of oxygen you're getting (PaO2/FiO2) of 200 or less.
- You must not have certain heart conditions, active bleeding, or have a pacemaker or recent chest wounds that prevent certain monitoring devices.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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