Compare diaphragm surgery versus breathing machine support
Part of Brain & nervous system, Lungs & breathing clinical trials.
This trial is studying whether surgery, instead of using a breathing machine, works better for people with one-sided diaphragm paralysis. It aims to improve breathing comfort and function in the right patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older.
- Have one-sided (unilateral) diaphragm paralysis from an isolated phrenic nerve injury.
- Your diagnosis should be at least 1 year old before starting treatment.
- Be able to give written consent (sign a study consent form).
- Have normal daytime carbon dioxide levels (not too high).
- Not have diaphragm paralysis affecting both sides.
- Not have another whole-body nerve/muscle disease causing diaphragm weakness (like ALS).
- No prior radiation to the chest and you must be eligible for diaphragm surgery.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial looks at how patients feel and recover after surgery to fix the nerve that controls the diaphragm. It aims to learn about people's experiences to improve care for diaphragmatic paralysis.
This trial tests if robot-assisted surgery to tighten the paralyzed diaphragm muscle can help people with long-term breathing difficulty on one side. It focuses on those whose paralysis has lasted at least a year and is not due to other muscle or nerve diseases.
This trial tests a device called AeroPace that helps stimulate the diaphragm to help people who have been on a breathing machine for a long time and have not been able to come off. It aims to see if the device is safe and effective in helping patients breathe on their own.
This study looks at how common diaphragm weakness is in people who have been on breathing support in the ICU. If you are coming off that support, researchers want to learn if your diaphragm strength affects your recovery.
This study tests whether specialized breathing exercises can help strengthen the breathing muscle (diaphragm) in patients on breathing machines in the ICU. Researchers will measure changes in the diaphragm's thickness and function.
This trial studies how the diaphragm (your main breathing muscle) and lung/airway tissue behave in people who are being supported until they can get a lung transplant. The results may help doctors better understand breathing failure and improve transplant care.
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