Proton vs photon radiation for esophageal cancer before surgery
Part of Cancer, Digestive system clinical trials.
This trial compares proton therapy and standard photon therapy given before surgery for esophageal (or stomach–esophagus) cancer. It aims to see which radiation approach works better and is safer as part of a combined treatment plan.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have confirmed esophageal or gastro-esophageal junction cancer, either squamous cell or adenocarcinoma (including signet cell or large cell types).
- Your cancer stage is M0 (no distant spread) but not early only: it should be cT1–4a and/or have lymph node involvement (cN+).
- You are 18 years or older and can do daily activities fairly well (WHO performance status 0–2).
- Recent scans include FDG PET/CT, and the study team plans curative treatment with radiation/chemotherapy followed by planned esophagus or stomach surgery (open or minimally invasive).
- Your blood counts and organ function are good enough (for example hemoglobin above 90 g/L, platelets at least 75, and kidney function with GFR above 30).
- If you can become pregnant, you must use highly reliable birth control and have a negative pregnancy test.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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