LAA closure study for people with atrial fibrillation
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a non-drug procedure to close a heart area called the left atrial appendage (LAA) to help prevent stroke in people with atrial fibrillation who are high risk. It’s for people who want to avoid taking long-term blood thinners, though they may need short-term medication after the procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18+ (and if you can get pregnant, you must not be pregnant).
- You have non-valvular atrial fibrillation (paroxysmal, persistent, or permanent).
- Your stroke risk is high (your CHA2DS2-VASc score is 3 or higher).
- Your care team believes you can take a blood thinner by mouth for a short time, but long-term blood thinners are not a good fit for you.
- A specialist agrees you are a good candidate for LAA closure using shared decision-making.
- You can follow the study visit schedule and take the required study medicines.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a left atrial appendage closure device for people with atrial fibrillation who need an alternative to long-term blood thinners. It aims to see if the procedure can be done safely with conscious sedation instead of general anesthesia.
This study looks at long-term outcomes after LAA closure (a procedure to reduce stroke risk) by reviewing CT scans of the device. It aims to learn if blood flow around the device affects healing and future health.
This trial tests the Zenith system, a device that seals off a heart area called the left atrial appendage to reduce stroke risk in people with atrial fibrillation (AF). You may be eligible if you have AF and a doctor recommends LAA closure, and you can return for follow-up scans and visits.
This trial tests a new device (LAmbre Plus) that closes off a small pouch in the heart (left atrial appendage) to reduce stroke risk in people with AFib who cannot take blood thinners long-term. The procedure is an alternative to daily medication.
This trial compares a heart device that can help prevent blood clots in the heart (called LAAO) versus long-term blood thinners for people who have atrial fibrillation and recently had a stent placed. It aims to see which approach better prevents stroke and related blood-clot problems while keeping side effects manageable.
This trial compares a simpler procedure to the standard one for closing the left atrial appendage in people with non-valvular atrial fibrillation. The goal is to see which approach works better for preventing strokes while lowering bleeding risks.
Hear when a new Atrial fibrillation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.