Azithromycin for chronic pus-filled sinus inflammation
Treatments studied
Part of Ear, nose & throat, Immune system & allergy, Infections, Lungs & breathing clinical trials.
This Phase 3 trial tests whether the antibiotic azithromycin can improve chronic sinus problems where there is persistent pus and swelling. It’s for adults who have not improved despite at least two prior antibiotics.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 to 69 years old
- You have chronic sinus disease lasting more than 12 weeks with pus and swelling seen on a nasal camera exam and a CT scan
- Your symptoms persist despite trying at least two different antibiotics
- You can complete health questionnaires in French (SNOT-22 and SF-36)
- You are not pregnant or breastfeeding and you can sign informed consent
- You have no key heart rhythm, major kidney/liver problems, or hearing loss that the study considers too severe
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 4 study tests whether a long course of azithromycin can reduce flare-ups in people with chronic obstructive pulmonary disease (COPD) who have had recent exacerbations. It also looks at mucus properties and how flare-ups happen.
This study tests whether taking a low dose of an antibiotic called azithromycin after sinus surgery helps reduce nasal polyps and improve symptoms. It is for adults with chronic sinusitis and nasal polyps who are not allergic to this type of medicine.
This trial tests a new nasal spray that combines exosomes (tiny cell messengers), azelastine (an antihistamine), and interferon (a protein that helps fight infections) for people with chronic sinusitis. It aims to reduce symptoms and improve your sinus condition.
This study tests whether applying an antibiotic through the skin using ultrasound (called phonophoresis) can reduce symptoms of chronic sinusitis. It may offer a non-surgical option for people with sinus inflammation.
This study tests whether a common antibiotic called azithromycin can help prevent flare-ups (sudden worsening) of bronchiectasis—a lung condition where airways become permanently enlarged and damaged. Patients will take azithromycin or a placebo for 12 months to see if it reduces how often they get sick.
This trial tests whether nasal steroids, nasal irrigation, or oral antibiotics work best for acute sinusitis. It may help if you have ongoing sinus symptoms or a 'double-sickening' pattern after a cold.
Hear when a new Sinusitis, Chronic trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.