Apomorphine for severe unresponsive brain injuries
Part of Brain & nervous system, Mental health clinical trials.
This trial tests whether apomorphine can improve care or outcomes for people in an unresponsive wakefulness or minimally conscious state after a brain injury. It is designed for patients who are medically stable and not currently on certain brain- or heart- affecting medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Ages 18 to 80, and the person is more than 4 weeks after the brain injury
- The person is not breathing through a ventilator (breathing without a breathing machine)
- They have been diagnosed as unresponsive or minimally conscious, based on repeat brain-behavior testing (CRS-R) in the past 14 days
- In the last 2 weeks, they have not taken dopamine-type medicines other than apomorphine, and no new neurological medicines besides seizure or spasticity medicines
- No major heart rhythm risk: recent ECG must not show a corrected QT over 480 ms, and they should not have serious heart/liver problems or major electrolyte problems
- They must be able to safely have brain testing like MRI, EEG, or PET (no contraindications) and have a legal representative able to consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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