Clinical trials
Disorder of Consciousness clinical trials
Below are recruiting disorder of consciousness clinical trials, each written for real people, not researchers. We’re tracking 60 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05823454Recruiting
Testing brain-connection changes during propofol sedation
This study looks at how the brain network connects during propofol sedation in people with long-lasting disorders of consciousness. It may help doctors understand brain function in these conditions and improve how care is guided during procedures.
BeijingAges 18–65 - NCT07694258Recruiting
Testing a helmet for brain stimulation in consciousness disorders
This study tests a special helmet that uses ultrasound to stimulate the brain in people with disorders of consciousness caused by brain injury. It aims to see if the treatment is safe and possible to do.
Toronto, OntarioAges Any age - NCT06930716Recruiting
Vagus nerve stimulation with physical therapy for consciousness disorders
This trial tests whether a mild electrical stimulation of the vagus nerve (a nerve in the neck) can help people with long-term disorders of consciousness move better during physical therapy. It may be an option if you are still in a coma, vegetative, or minimally conscious state and have been stable for more than 6 weeks.
New York, New YorkAges 22 years+ - NCT06939348Recruiting
Ultrasound therapy for patients with consciousness disorders
This trial tests whether ultrasound stimulation can help people with disorders of consciousness, like coma or a minimally conscious state. It aims to improve brain function and recovery for patients who have been injured for over a month.
Los Angeles, CaliforniaAges 18–79 - NCT07485361Recruiting
Brain scanning in disorders of consciousness
This trial uses a portable brain scanner (fNIRS) to study brain activity in people with disorders of consciousness, like coma or minimally conscious states. It may help doctors better understand and track recovery in these patients. Healthy volunteers are also needed as a comparison group.
Los Angeles, CaliforniaAges 18 years+ - NCT04534777Recruiting
Tests ways to predict recovery after brain injury
This study looks at different ways to predict how people with severe disorders of consciousness might recover after a brain injury. It may help doctors better estimate prognosis and improve care planning.
ParisAges 18–80 - NCT06088628Recruiting
Facial micro-expressions in long-term consciousness disorders
This study looks at tiny, unconscious facial expressions in patients who have been in a vegetative or minimally conscious state for over a month after a severe brain injury. The goal is to see if these micro-expressions can help doctors better understand a patient's level of awareness.
Hangzhou, ZhejiangAges 18–80 - NCT06406413Recruiting
Micro-movements in prolonged disorders of consciousness
This trial studies tiny, subconscious movements in people who have been in a coma or minimal consciousness for over a month after a severe brain injury. It aims to understand these movements better, which could help improve care and communication.
Hanzhou, ZhejiangAges 18–80 - NCT06851156Recruiting
Brain stimulation for disorders of consciousness after severe injury
This trial tests a new type of brain stimulation called transcranial temporal interference stimulation to see if it can help people with severe brain injury who are in a vegetative or minimally conscious state. It uses gentle electrical currents to try to improve awareness and recovery.
Xi'an, ShaanxiAges 18–65 - NCT06896279Recruiting
Temporal interference brain stimulation for consciousness disorders
This trial tests a new type of brain stimulation called temporal interference (TI) to see if it can help people with severe disorders of consciousness. If you or your loved one has been in a minimally conscious or vegetative state for at least a month and is medically stable, this study may be an option.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07277309Recruiting
Recovery after brain injury using focused ultrasound
This study tests whether focused ultrasound can help people recover from a brain injury that has left them with a disorder of consciousness. The treatment involves a non-invasive technique that uses sound waves to stimulate brain activity.
Boston, MassachusettsAges 18–79 - NCT06473285Recruiting
Esketamine for consciousness in prolonged disorders of consciousness
This trial tests whether a drug called esketamine can help improve brain activity in people with long-term disorders of consciousness. It may help doctors understand how the brain recovers.
BeijingAges 18–65 - NCT07535593RecruitingPhase 2/Phase 3
Electrical Acupoint Stimulation for Consciousness Disorders
This trial tests a non-invasive treatment called transcutaneous electrical acupoint stimulation (TEAS) to help people recover consciousness after severe brain injury. The treatment uses mild electrical pulses on specific points on the hands and may help improve awareness and responsiveness.
Xi'an, ShaanxiAges 18–80 - NCT03827187Recruiting
Brain signal training to detect awareness
This study checks whether brain activity patterns can show when a person is aware, even if they can’t reliably communicate. If signs of awareness are found (or if you already know you are aware), the study may also train a brain-computer interface to support communication or movement assistance.
DublinAges 10–80 - NCT04427241RecruitingPhase 4
Testing Cerebrolysin for prolonged brain injury after bleeding stroke
This study tests whether Cerebrolysin can improve recovery in people who remain in a vegetative or minimally conscious state more than 4 weeks after a bleeding stroke. It also tracks safety, to make sure the treatment is not causing harmful side effects.
SeoulAges 19–120 - NCT04445649Recruiting
Find factors to help people regain consciousness after brain injury
This study looks at what predicts recovery of consciousness after certain serious brain injuries, such as stroke or traumatic brain injury. It may help clinicians better identify which patients are more likely to wake up and guide early rehabilitation and care.
Hessisch OldendorfAges 18–85 - NCT06323031Recruiting
Eye Blinking in Disorders of Consciousness
This study looks at how people with disorders of consciousness (like being in a coma or a minimally conscious state) blink their eyes. Researchers want to see if eye blinking patterns can tell us more about their awareness, which may help with treatment.
Liège, BelgiumAges 18 years+ - NCT05740735Recruiting
Testing sound-based brain signals to predict recovery after severe brain injury
This study checks how a brain responds to two kinds of sounds—neutral tones and emotional sounds—in people with a persistent disorder of consciousness after a serious event like stroke, head injury, or cardiac arrest. The goal is to see whether these brain “signal” tests can help doctors predict outcomes.
Paris, IDFAges 18 years+ - NCT06268236Recruiting
Electro-acupuncture for awareness after severe brain injury
This study tests whether a type of acupuncture that uses mild electric pulses (called electro-acupuncture) can help people who have a reduced level of awareness after a severe brain injury. The goal is to see if it improves recovery.
Guangzhou, GuangdongAges 18 years+ - NCT06527573Recruiting
Brain stimulation for consciousness after injury
This study tests if a special brain stimulation technique (repetitive transcranial magnetic stimulation, or rTMS) can help people with disorders of consciousness after a recent brain injury. Researchers want to see if stimulating different spots on the brain improves recovery.
Guangzhou, GuangzhouAges 18–70 - NCT06959212Recruiting
Memory study in patients with disorders of consciousness
This trial studies memory abilities in people who are unconscious due to a brain injury. It compares unconscious patients, conscious patients in intensive care, and people who have recovered consciousness after being unconscious. Participation involves memory testing and may help us understand how the brain recovers.
ParisAges 15 years+ - NCT07284732Recruiting
Ear nerve stimulation for consciousness disorders
This trial tests whether a gentle electrical stimulation on the ear can help people with disorders of consciousness, like a vegetative or minimally conscious state. It aims to see if this noninvasive treatment can improve brain function and awareness.
Guangzhou, GuangdongAges 18–70 - NCT07074678Enrolling by invitation
Predicting recovery in early consciousness disorders
This study uses brain scans to understand how people with severe brain injuries may recover consciousness. It is for patients who have had a recent brain injury and are in a coma, vegetative state, or minimally conscious state.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06426602Enrolling by invitation
Brain communication trial for disorders of consciousness
This trial tests a new way to help people with disorders of consciousness (like locked-in syndrome) communicate using their brain activity. The goal is to see if a special system can unlock better communication for those who have limited ability to speak or move.
Pittsburgh, PennsylvaniaAges 16–65
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Disorder of Consciousness trials by city
Studies with a site in or near these metro areas.
Disorder of Consciousness trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for disorder of consciousness?
- Yes. Clin2 currently lists 60 recruiting disorder of consciousness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disorder of consciousness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disorder of consciousness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.