Study sedative effects on ongoing brain inflammation after severe COVID
Part of Brain & nervous system, Infections, Lungs & breathing clinical trials.
This study looks at whether a specific ICU sedative (dexmedetomidine) affects long-term inflammation in the brain after severe COVID with ARDS and deep sedation. It uses PET and MRI scans and special tracers to understand persistent inflammation and why it may last.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re an adult (18–74 years old).
- You had COVID confirmed by a lab test (PCR) from a nose or lung sample.
- You were in the ICU for COVID-related ARDS and needed a breathing machine and deep sedation for at least 24 hours.
- You have a specific gene test result for the study tracer, or you may not be eligible.
- You can undergo PET and MRI scans, and there are no scan-related safety problems.
- You have no major exclusions like pregnancy/breast-feeding, severe kidney problems, or certain serious brain history (stroke, severe head injury, dementia with loss of independence).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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