New drug combo for agitation in ICU delirium patients
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests if combining two medicines, esketamine and dexmedetomidine, is better than dexmedetomidine alone for calming severe confusion and agitation in ICU patients who need breathing support through a mask or nasal tubes. It aims to find a safer, more effective way to help patients rest and recover.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You are currently in the ICU and expected to stay for at least 24 hours.
- You have severe confusion (delirium) with agitation, as assessed by standard ICU tests.
- You are receiving non-invasive breathing support (like high-flow oxygen or a CPAP mask) for more than 24 hours.
- You are not pregnant or breastfeeding.
- You have no history of epilepsy, severe heart rhythm problems, or very poor liver or kidney function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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