Combination sedative for delirium in ICU patients on breathing support
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests whether combining two sedative medications, esketamine and dexmedetomidine, is safer and more effective than using dexmedetomidine alone for treating hyperactive delirium in ICU patients who need breathing support. If you or a loved one are experiencing severe confusion and agitation while on a breathing machine, this study may offer a new treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You are currently in the intensive care unit (ICU) and expected to stay for more than 24 hours.
- You have hyperactive delirium, which means you are very agitated and confused, as confirmed by a standard assessment.
- You have been receiving non-invasive breathing support (like a high-flow nasal cannula or CPAP) for more than 24 hours.
- You do not have any severe heart rhythm problems, recent use of similar sedatives, or other conditions that would make the study unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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