Ablation treatment after failed electric heart shock
Part of Heart & circulation clinical trials.
This trial tests whether blocking faulty heart signals from the pulmonary veins (with or without additional “substrate” modification) works better when electric cardioversion doesn’t stop persistent atrial fibrillation. It may help people who remain in atrial fibrillation after cardioversion by reducing symptoms and abnormal rhythm over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have persistent atrial fibrillation (AF) lasting at least 7 days, and it keeps causing symptoms despite at least one anti-arrhythmia medicine (including amiodarone).
- You either: (a) are planned for ablation 4–6 weeks after electric cardioversion, or (b) have persistent AF that didn’t respond to electric cardioversion, with AF still seen on an ECG.
- You are between 18 and 80 years old (at the time of electric cardioversion) and your expected lifespan is more than 5 years.
- You are enrolled with health insurance, and you can sign informed consent.
- You must not have key health conditions that increase risk, such as untreated thyroid overactivity, pregnancy, BMI over 35, or severe COPD.
- You must not have certain heart conditions or major medication/health limitations (examples: a heart valve replacement in the mitral position, cannot take blood thinners, recent stroke/TIA within 6 months, very weak heart pumping).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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