Opening the blood-brain barrier for ALS treatment
Part of Brain & nervous system, Hormones & metabolism clinical trials.
This trial tests a device that temporarily opens the barrier between the blood and brain to see if it can help slow down ALS. It may allow treatments to reach the brain more effectively.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have a confirmed diagnosis of ALS affecting both upper and lower motor neurons.
- Your symptoms started within the last 3 years.
- Your physical function is still relatively good (score of 30 or higher on a standard ALS scale).
- You have not needed a breathing machine or feeding tube yet.
- You are not taking certain ALS medications like edaravone or tofersen.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies an experimental drug called LTX-002 for people with ALS. It aims to see if the drug is safe and can slow down the disease.
This trial tests a new treatment aimed at restoring the function of a gene called UNC13A in people with ALS. It involves multiple clinic visits, MRI scans, and spinal taps to see if the treatment is safe and may slow the disease.
This trial tests a brain-computer interface (BCI) device that lets people with ALS communicate using brain signals, without needing to move. It may help those who have difficulty speaking or using eye-gaze devices.
This trial tests a new way of giving riluzole, a medicine already used for ALS, by delivering it directly into the fluid around the spinal cord using a small pump. It aims to see if this method is safe and might work better for people with ALS.
This study is testing whether injecting special cells (called Q-Cells) into the spinal cord is safe for people with ALS. It's an early-stage trial, so the main goal is to check safety, but it might help slow down the disease in the future.
This trial tests whether repetitive TMS (transcranial magnetic stimulation) can help people with ALS. It uses a special type of TMS that is repeated and measured. You would lie comfortably for about an hour while receiving the treatment.
Hear when a new Amyotrophic Lateral Sclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.