Clin2
NCT05332691Possibly a fitRecruiting

Beating-heart septal myectomy for thick-heart blockage

Hypertrophic Obstructive Cardiomyopathy

Part of Heart & circulation clinical trials.

This trial studies surgery that removes part of the thick heart muscle while the heart is still beating to relieve a blockage that makes blood leaving the heart harder. It may help people with hypertrophic obstructive cardiomyopathy whose symptoms persist despite medication.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
1,000 people
Ages
8 years and older
Study type
Interventional

Who can take part

  • You have a strong blockage from your heart at rest or after a test (gradient over 50 mmHg)
  • You have a very thick heart septum (septal thickness at least 15 mm)
  • Your symptoms are at least moderate (New York Heart Association class II or higher)
  • Medication didn’t help enough, or you couldn’t tolerate it
  • You can sign consent after understanding what the study involves

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07006493Recruiting
Radiofrequency ablation for obstructive hypertrophic cardiomyopathy

This trial tests a new treatment that uses radiofrequency energy (similar to heat) to shrink the thickened heart muscle blocking blood flow. It is for people with obstructive hypertrophic cardiomyopathy who have symptoms despite medication and are not able or willing to have heart surgery.

Beijing, Beijing Municipality
NCT06683872Enrolling by invitation
CT heart modeling for hypertrophic obstructive cardiomyopathy

This trial uses a special CT scan to create a 3D model of your heart's blood flow. It aims to see if this model can help doctors better predict how well treatments work for people with a thick heart muscle that blocks blood flow.

Hangzhou, Zhejiang
NCT06977646Enrolling by invitation
Heart surgery for apical hypertrophic cardiomyopathy without valve pressure

This study looks at people who have had surgery to reshape the left side of the heart for a specific type of thickened heart muscle (apical hypertrophic cardiomyopathy). It helps doctors understand how well this surgery works in patients without a large pressure difference across the heart valve.

Moscow, Moscow
NCT07806149Not yet recruiting
A new catheter procedure to treat thickened heart muscle

This study tests a new, less invasive procedure called SESAME that uses a special catheter to carefully trim the thickened heart muscle wall (septum) to improve blood flow and reduce symptoms. It's for people with hypertrophic cardiomyopathy or those at risk of obstruction during mitral valve replacement.

Washington D.C., District of Columbia
NCT05818605Recruiting
Exercise training for people with hypertrophic heart muscle

This study tests whether a 24-week exercise program can improve exercise tolerance in people with hypertrophic cardiomyopathy (a thickened heart muscle). You may be asked to use phone-based tools and complete surveys during training.

San Francisco, California
NCT07865364Not yet recruiting
Treating chest pain in hypertrophic cardiomyopathy with a coronary sinus reducer

This study tests a device called a coronary sinus reducer for people with hypertrophic cardiomyopathy (a condition where the heart muscle is thickened) who still have symptoms like chest pain. The device is placed in a vein of the heart to improve blood flow and reduce symptoms.

Bristol

Hear when a new Hypertrophic Obstructive Cardiomyopathy trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.