Study of brain and memory changes in cortisol-producing adrenal conditions
Part of Brain & nervous system, Hormones & metabolism clinical trials.
This study tracks thinking and brain changes over time in people with adrenal findings that produce too much cortisol (a stress hormone) on their own. It may help doctors understand how different treatments or watchful waiting affect the brain and cognition.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re between 20 and 65 years old.
- You have at least 6 years of education and can complete all memory/thinking tests.
- You have an adrenal lesion (spot on the adrenal gland) that is at least 1 cm.
- You were told it is an adrenal adenoma that is “non-functioning,” but you still have autonomous cortisol secretion (cortisol is acting on its own).
- You must be able to have MRI scans (no metal implants that prevent MRI, and you’re not too claustrophobic).
- In the past 3 months, you have not taken steroid medicines or other drugs that change steroid production or breakdown.
- You do not have conditions like active cancer, recent serious infection (within 1 month), brain injury/stroke problems, or specific adrenal hormone disorders (Cushing syndrome/disease, primary hyperaldosteronism, or pheochromocytoma).
- You are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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