Study of new thinking skills in hard-to-treat depression
Part of Mental health clinical trials.
This trial looks at how people with treatment-resistant major depression respond when starting a new depression medicine that affects glutamate signaling. It also involves brain scans and thinking/learning tasks, aiming to understand what helps people improve when standard treatments haven’t worked.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re between 18 and 70 years old
- You have major depression that has not improved after at least two different antidepressant trials
- Your depression severity is at least “20” on the MADRS scale (a clinician-rated questionnaire)
- You can understand the instructions and complete required behavioral tasks
- You must be able to have an MRI scan safely (for example, no pacemaker/metal in the body and not too claustrophobic)
- You are not currently pregnant and are not under legal protection/guardianship
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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