Explaining nerve signals in teens with POTS
Part of Brain & nervous system clinical trials.
This study looks at how a specific brain–vagus nerve connection works in people with POTS and tries to understand what happens over time. It may help researchers better explain symptoms and other health problems that can occur with POTS.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are female and age 12–21 years old
- You can communicate and give assent/consent (and speak English)
- You have a POTS diagnosis: heart rate rises by at least 40 beats/min when standing without a blood pressure drop, with symptoms
- You do not have another ongoing long-term nervous system condition besides POTS
- You do not have certain autoimmune/inflammatory diseases or nerve-related conditions (like MS, seizures, stroke, or major neuropathy)
- You have no major unstable heart/lung/kidney/liver/endocrine/mental health problems, and are not recently started on unapproved devices or medicines
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether improving your vagal nerve function can change how a brain area called the periaqueductal gray communicates, which might help with POTS or fainting symptoms. It involves breathing exercises and an MRI scan to see if there are beneficial changes in the brain.
This trial studies people with POTS (a condition where heart rate rises when you stand) and compares them with people without POTS. It tests body “adrenergic” (stress-chemistry) signals and how the body handles posture, which may help researchers find better ways to manage POTS.
This trial studies whether an autoimmune (immune system–related) process is involved in postural tachycardia syndrome (POTS), a condition where your heart rate rises when you stand. The study may help researchers understand what causes POTS and how it could be treated or monitored.
This study measures how breathing patterns and heart rate/blood pressure change when you move from lying to standing in people with POTS. It may help researchers understand symptoms better and improve ways to manage them.
This study looks at why some people develop POTS (a condition that causes a fast heart rate and dizziness when standing) and if it's linked to how the brain and vagus nerve work together. It also includes people recovering from a serious infection and healthy volunteers for comparison.
This study looks at how the body controls heart rate and blood flow in people with POTS (a condition that causes dizziness and a fast heart rate upon standing). It helps researchers understand POTS better by comparing patients with healthy volunteers.
Hear when a new Postural Tachycardia Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.