Semaglutide shot for early stroke recovery
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This Phase 2 study tests whether a semaglutide injection given under the skin soon after an acute ischemic stroke can improve recovery. It may help reduce disability, especially if treatment starts within about 4.5 hours of symptom onset.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older (you can consent or have a proxy consent).
- Your stroke was ischemic (a blockage in a blood vessel), with disabling symptoms affecting functions like speech or movement.
- Your stroke symptoms started (or last known well) less than 4.5 hours before you are randomized.
- Before the stroke, you were not very disabled in daily life (pre-stroke score 0 to 3).
- Your blood sugar is not high and you do not have known diabetes.
- Your kidney function is adequate (eGFR is 30 or higher).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if semaglutide, a diabetes drug, can improve brain recovery after a stroke when given within 24 hours of symptom onset and before a clot-removal procedure. It may help reduce disability and improve neurological outcomes.
This study tests a medicine (a GLP-1 receptor agonist) given along with the standard clot-removal procedure for people who have had a severe stroke from a large blockage. The goal is to see if the medicine helps improve recovery by protecting the brain.
This trial tests whether semaglutide (a diabetes drug) can help protect kidney function in people with type 2 diabetes who already have mild to moderate kidney damage. You will take semaglutide or a placebo and have regular kidney function tests.
This trial tests whether semaglutide changes blood flow in the brain and the brain’s “barrier” (how well the brain is protected) in people with type 2 diabetes. It may help researchers understand brain-related effects of diabetes treatment using scans and blood tests.
This study tests if adding a GLP-1 receptor agonist (a type of diabetes medicine that also helps blood vessels) to standard clot removal can improve recovery after a severe stroke. It is for people who had a clot removal for a large artery blockage and can start the drug within 6 hours.
This study tests if a daily semaglutide pill can reduce harmful fat around the heart in people with type 2 diabetes who had a heart attack 2 to 9 months ago. It aims to see if this treatment can improve heart health.
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