Methylphenidate for apathy in Parkinson’s patients
Treatments studied
Part of Brain & nervous system clinical trials.
This study tests whether methylphenidate can reduce apathy (lack of motivation) in people with Parkinson’s disease. It may help if apathy has been persistent for weeks and your Parkinson’s medicines have been stable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have Parkinson’s disease (or a probable Parkinson’s diagnosis) confirmed by standard criteria
- You are age 40 or older
- Your thinking tests and dementia rating must be in the eligible range (MoCA 17–30; CDR below 1)
- You have clinically significant apathy for at least 4 weeks (happening often and with moderate to marked severity)
- Your Parkinson’s medicines have not changed in the last month, and related meds are stable as required
- You and your main caregiver must speak and read English well, and your caregiver can attend visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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