Medication study for lack of motivation in Parkinson's disease
Treatments studied
Part of Brain & nervous system clinical trials.
This study tests a medicine called methylphenidate (often used for ADHD) to see if it helps reduce apathy—feelings of lack of motivation or interest—in people with Parkinson's disease. If it works, it could improve your quality of life and daily functioning.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 40 years or older and have a diagnosis of Parkinson's disease.
- You have significant feelings of apathy (lack of motivation) for at least 4 weeks.
- You have a caregiver who can join you at study visits and help with the study.
- You are not on certain medications that could be risky with the study drug.
- You do not have major heart problems, severe mental health issues, or certain other health conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new drug called IRL757 to see if it is safe and helps with apathy (loss of motivation or interest) in people with Parkinson's disease. You need to have at least moderate apathy and a caregiver who can come to visits with you.
This trial tests a new approach using deep brain stimulation (a treatment that uses tiny electrical pulses in the brain) to help with severe apathy—a common and hard-to-treat symptom of Parkinson's disease where you lose interest and motivation. If you've tried medications without success, this study might offer another option.
This study tests whether a non-invasive brain stimulation treatment called TMS (transcranial magnetic stimulation) can help improve apathy, or loss of motivation, in people with Parkinson's disease. You must have had symptoms for at least 4 years and be on stable Parkinson's medications.
This study tests if combining a type of brain stimulation (repetitive TMS) with a medication (methylphenidate, commonly used for ADHD) can improve apathy in people with dementia. If you have Alzheimer's or mixed dementia and struggle with low motivation, this trial may help you.
This study tests whether music can help reduce apathy (low motivation) in people with Parkinson’s disease. It may help your mood and daily drive by targeting brain and behavior pathways tied to apathy.
This trial tests an experimental drug called AP-472, taken alongside your regular Parkinson's medications, to see if it can reduce the amount of "OFF" time you experience each day when symptoms return between doses of levodopa.
Hear when a new Apathy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.