Clinical trials
Apathy clinical trials
Below are recruiting apathy clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07279740RecruitingPhase 2
Brain stimulation plus medication for apathy in dementia
This study tests if combining a type of brain stimulation (repetitive TMS) with a medication (methylphenidate, commonly used for ADHD) can improve apathy in people with dementia. If you have Alzheimer's or mixed dementia and struggle with low motivation, this trial may help you.
Toronto, OntarioAges Any age - NCT07404410Recruiting
Robot therapy for apathy in dementia
This study tests whether a friendly robot can help reduce apathy (loss of interest) in people with dementia. You and your caregiver will use the robot at home for several weeks.
Milan, ItalyAges 40 years+ - NCT03998852RecruitingPhase 3
PET study of brain chemical changes in stroke apathy
This Phase 3 trial uses special brain scans (PET) to understand what brain chemical systems are involved in apathy after stroke. Your results may help researchers better understand the cause of apathy and guide future treatments.
BordeauxAges 18–75 - NCT04757220Recruiting
Study of apathy in people with schizophrenia or depression
This study looks at “apathy,” or reduced motivation/interest, in people with schizophrenia or depression. It may help researchers understand what drives apathy and how to measure it in a clearer, more complete way.
StrasbourgAges 18–60 - NCT05505019Recruiting
Using music to reduce apathy in Parkinson’s disease
This study tests whether music can help reduce apathy (low motivation) in people with Parkinson’s disease. It may help your mood and daily drive by targeting brain and behavior pathways tied to apathy.
Vancouver, British ColumbiaAges 40–85 - NCT05561205Recruiting
Brain stimulation to treat persistent apathy
This trial tests a noninvasive brain stimulation treatment (called rTMS) to help people who have had ongoing apathy (lack of motivation/interest) for at least a month. You might benefit if your apathy is persistent, your other symptoms are stable, and you meet the safety and medication rules.
Toronto, OntarioAges Any age - NCT05877885Recruiting
Digital treatment for low motivation in older adults with depression
This study tests a digital therapy to improve apathy (feeling unmotivated or “checked out”) in people age 60+ who have depression. It also uses brain imaging (MRI) and questionnaires to see whether the treatment helps brain function linked to motivation.
Orlando, FloridaAges 60 years+ - NCT06482554RecruitingPhase 3
Lumateperone for Apathy in Psychotic Disorders
This trial tests a medication called lumateperone to see if it can improve apathy (lack of motivation) in people who have psychotic symptoms from schizophrenia or related disorders. It may help if you are already on a stable treatment but still struggle with apathy.
Shreveport, LouisianaAges 18–65 - NCT06914284Recruiting
Apathy and thinking changes in older adults with bipolar disorder
This study looks at whether apathy and certain brain markers can help predict memory and thinking problems in people over 70 with bipolar disorder. If you are 70-85, have bipolar disorder, and are currently stable (no recent mood episodes), you may be able to join.
Rennes, Ile Et VilaineAges 70–85 - NCT06919094Recruiting
Virtual club to reduce loneliness in older adults
This trial tests whether a virtual life story club can help older adults feel less lonely and more engaged. You would meet with others online to share memories and stories.
The Bronx, New YorkAges 60 years+ - NCT07113067RecruitingPhase 1/Phase 2
Accelerated rTMS for Stroke Apathy
This study tests a non-invasive brain stimulation treatment called rTMS to see if it can help reduce apathy (lack of motivation) after a stroke. You would receive either real rTMS or a sham (fake) treatment over several sessions.
Charleston, South CarolinaAges 40 years+ - NCT07118956Recruiting
Ear stimulation for apathy in Parkinson's
This trial tests whether a gentle electrical stimulation on your ear (taVNS) can help improve low motivation (apathy) in people with Parkinson's. It also uses MRI scans to see how the treatment affects the brain.
Hefei, AnhuiAges 40–90 - NCT07237009Recruiting
Personalized reminiscence therapy for memory loss
This trial tests a digital app that uses personal photos and memories to help people with early memory problems feel less depressed or apathetic. It's designed for seniors who have mild cognitive impairment or early dementia.
AngersAges 60 years+ - NCT07461220RecruitingPhase 1/Phase 2
Testing IRL757 for apathy in Parkinson's disease
This trial tests a new drug called IRL757 to see if it is safe and helps with apathy (loss of motivation or interest) in people with Parkinson's disease. You need to have at least moderate apathy and a caregiver who can come to visits with you.
PlevenAges 50–90 - NCT06087926Recruiting
TMS for apathy in Parkinson's disease
This study tests whether a non-invasive brain stimulation treatment called TMS (transcranial magnetic stimulation) can help improve apathy, or loss of motivation, in people with Parkinson's disease. You must have had symptoms for at least 4 years and be on stable Parkinson's medications.
Chapel Hill, North CarolinaAges 55–80 - NCT07146503Recruiting
Esketamine Nasal Spray for Treatment-Resistant Depression in Real Life
This study tests esketamine nasal spray (a fast-acting antidepressant) for people with treatment-resistant depression who haven't gotten better after trying at least two other antidepressants. It looks at how well the spray works in everyday doctor's offices, not just in research clinics.
Genova, GeAges 18–74 - NCT07399496Recruiting
Fast TMS for apathy in Parkinson's disease
This study tests a faster version of TMS (transcranial magnetic stimulation) to see if it can help with apathy—low motivation and lack of interest—in people with Parkinson's disease. You will receive several TMS sessions each day over a short period, and the study team will check if your mood and motivation improve.
Charleston, South CarolinaAges 45–85 - NCT06642454Enrolling by invitation
Breathing-guided nerve stimulation for Parkinson's disease
This study tests a type of nerve stimulation (vagus nerve) for Parkinson's disease. It compares a method that uses your breathing cycle to deliver stimulation versus standard stimulation. The goal is to see which works better for movement and non-movement symptoms.
Hefei, AnhuiAges 40–80
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Common questions
- Are there clinical trials for apathy?
- Yes. Clin2 currently lists 18 recruiting apathy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a apathy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a apathy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.