Testing how mepolizumab works for people with nasal polyps
Treatments studied
Part of Ear, nose & throat, Immune system & allergy, Lungs & breathing clinical trials.
This study looks at blood and other measures (biomarkers) to understand how well mepolizumab helps people with nasal polyps, with or without asthma. It aims to find response clues that could help personalize treatment in the future.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re an adult (age 18 or older) with nasal polyps on both sides
- Your nasal symptoms are severe despite standard treatment (score for each symptom adds up to more than 24 on a 0–10 scale)
- You need nasal polyp surgery, based on specific scan/symptom scores (Lund-Mackay and Lund-Kennedy) and ongoing symptoms for at least 12 weeks
- If you have asthma, it must be confirmed by documented history/testing (like bronchodilator response or methacholine test)
- You must not be pregnant or breastfeeding, and must not be of child-bearing potential unless safety rules allow it
- You can’t have used mepolizumab or similar biologic medicines before (or recently), and you can’t use certain immune-suppressing medicines in the recent past
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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