Preventing hearing damage from IV amikacin in NTM patients
Part of Brain & nervous system, Ear, nose & throat, Injuries & trauma clinical trials.
This Phase 2 study looks at ways to prevent hearing damage (ototoxicity) in people with NTM lung infection who are treated with IV amikacin. If you qualify, the study may help protect your hearing while you receive a treatment that can sometimes affect hearing.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to under 80 years old and can sign consent yourself
- You have a lung NTM infection that normally needs IV amikacin, and it’s expected to last at least 30 days
- You can follow daily study steps and take any oral medicines as instructed
- You can use effective contraception (or no sex) during treatment and for a set time after the last dose
- Your recent antibiotic and amikacin history fit the study rules (no aminoglycoside exposure in the last 6 months)
- Your heart rhythm and ear exams are safe for the study (specific ECG limits and no major ear problems)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at hearing problems caused by cancer treatments that can damage the ears or nervous system. It aims to better understand and diagnose these side effects to help patients.
This trial tests if taking N-acetylcysteine (NAC) can help prevent hearing loss caused by high-dose cisplatin chemotherapy. If you're getting cisplatin and are between 18 and 70, you may be able to join.
This trial tests whether inhaling an antibiotic called amikacin can prevent ventilator-associated pneumonia in patients with severe liver disease (cirrhosis) who are on a breathing machine. If you or your loved one is in the ICU with liver issues and needs a ventilator, this study may help reduce the risk of a serious lung infection.
This trial tests if taking N-acetylcysteine (NAC) alongside standard TB treatment can help prevent long-term lung problems after tuberculosis. It is for people with moderate to severe TB who already have some reduced lung function.
This Phase 2 trial tests whether sodium thiosulfate and mannitol can reduce hearing damage (ototoxicity) in adults receiving cisplatin chemotherapy. It may help protect hearing while you get cancer treatment.
This trial tests a new drug called ACOU085 to prevent hearing loss in men with testicular cancer who are receiving cisplatin chemotherapy. If you meet the hearing and health criteria, you may be able to join and help see if this drug can protect your hearing.
Hear when a new Ototoxicity, Drug-Induced trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.