Study how the aorta changes after a valve procedure
Part of Genetic & congenital, Heart & circulation clinical trials.
This trial looks at how the ascending aorta (the main artery near the heart) changes over time after transcatheter aortic valve replacement. It may help doctors predict who is at risk of aorta enlargement after this less-invasive valve procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe aortic stenosis (a very tight aortic valve), such as valve area 1.0 cm² or less, or a smaller “indexed” value.
- You have symptoms from your valve problem—your heart doctor classifies you as New York Heart Association (NYHA) class 2 or higher.
- Your surgical team considers you high risk for open-heart (surgical) valve replacement.
- Your doctors think the procedure can be done through the groin artery (transfemoral access).
- You must not have mainly “dominant” aortic regurgitation (valve leaking as the main problem).
- You have not had previous aortic valve replacement or prior aortic surgery, and you don’t have connective tissue disorders.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests two types of replacement heart valves (self-expanding and balloon-expanding) in people who have severe aortic stenosis (tight heart valve) and an enlarged aorta (the main blood vessel from the heart). The goal is to see which valve type works better for these patients.
This study follows adults who are having aortic valve replacement (through surgery or a catheter) to see how often certain outcomes happen after the procedure. You may be asked for blood tests and scans at set times, and some people may also be offered a special CT scan.
This study compares two types of replacement heart valves used in a procedure to treat aortic stenosis (a narrowed heart valve). It aims to see which valve is safer by measuring tiny particles that may travel to the brain during the procedure.
This study looks at how replacing a narrowed heart valve affects fluid in the lungs. It may help doctors better understand recovery after this procedure.
This study looks at blood and/or body signals (called biomarkers) to understand why aortic valve narrowing may worsen and what outcomes people have. You may be able to help researchers by undergoing regular heart care plus additional testing like MRI or CT if you qualify.
This study looks for biological markers in the blood that might help predict heart-related events in people with a narrowed aortic heart valve. It aims to improve care for those with this condition, whether or not they have a procedure called TAVI to replace the valve.
Hear when a new Aortic Stenosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.