Clinical trials
Aortic Stenosis clinical trials
Below are recruiting aortic stenosis clinical trials, each written for real people, not researchers. We’re tracking 198 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03972644Recruiting
Early valve replacement for people with severe but silent aortic narrowing
This trial tests whether replacing a badly narrowed aortic valve earlier—even when you feel fine—can prevent future heart problems. It compares early valve replacement (through a catheter or surgery) versus standard watchful waiting.
Odense, FynAges 18–85 - NCT04893603Recruiting
TAVR valve test for severe, hard-to-pump heart valve
This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
BeijingAges 70 years+ - NCT04722796Recruiting
TAVR for bicuspid aortic valve with a specific device
This study tests a “solution” approach using a self-expanding valve during TAVR (a less invasive way to replace a narrowed aortic valve). It aims to improve how well the valve fits and works in people with a specific heart valve shape (bicuspid aortic stenosis).
Bengbu, AnhuiAges 60 years+ - NCT06136429Recruiting
A study of a new valve device for severe aortic stenosis
This trial tests a new valve device placed through a small tube (catheter) to treat severe aortic stenosis, a condition where the aortic valve is narrowed and doesn't open fully. It's for patients who cannot have traditional open-heart surgery.
BeijingAges 70 years+ - NCT03003299Recruiting
Valve replacement for failing aortic bioprosthetic valves
This trial studies a new “valve-in-valve” procedure to treat a failing aortic bioprosthetic valve. It may help people improve blood flow through the heart valve and reduce valve-related problems.
Phoenix, ArizonaAges Any age - NCT06235385Recruiting
European study on multiple and mixed valve disease
This study looks at people with multiple or mixed heart valve disease (moderate or severe) using echocardiography. It aims to learn more about how these conditions affect patients and help guide future care.
Paris, Île-de-France RegionAges 18 years+ - NCT07715279RecruitingPhase 2
Vericiguat for slowing aortic valve calcium buildup
This trial tests if the drug vericiguat can slow down the buildup of calcium in the aortic valve, which causes it to narrow and stiffen. If you have mild-to-moderate aortic valve stenosis and meet the other criteria, this study may help protect your valve from getting worse.
Chengdu, SichuanAges 35–80 - NCT07620925Recruiting
Aortic Valve Calcium Score Study Using Heart Ultrasound
This study develops and tests a new way to diagnose severe aortic stenosis (narrowing of the aortic valve) by measuring calcium buildup on the valve using heart ultrasound. If you're already getting both an ultrasound and a CT scan of your heart, this study compares how well the ultrasound method can identify severe stenosis.
BolognaAges 18 years+ - NCT06706635Recruiting
Better info for aortic stenosis patients before TAVI
This trial tests whether giving extra information before heart valve replacement (TAVI) helps patients feel more informed and improves their reported outcomes. If you have severe aortic stenosis and are planning to get a TAVI, this study may be for you.
Bad OeynhausenAges 18 years+ - NCT06168123Recruiting
Future care for aortic stenosis
This research study is a registry that collects information about people with aortic stenosis, a condition where a heart valve becomes narrow. The goal is to learn more about how this condition is managed and to improve future care.
NieuwegeinAges 18–110 - NCT06377449Recruiting
Lung ultrasound for better outcomes after heart surgery
This study tests whether using ultrasound to look at the lungs during and after heart surgery helps improve recovery. You may be eligible if you are having open-heart surgery with a heart-lung machine and meet certain health criteria.
Saint Petersburg, Sankt-PeterburgAges 18 years+ - NCT04913870RecruitingPhase 4
Tested blood pressure pills for mild to moderate aortic narrowing
This study tests whether angiotensin receptor blocker (ARB) blood pressure medication helps people with mild to moderate aortic stenosis (a narrowing of the heart’s main valve). It looks at safety and whether the treatment offers benefit for your heart and blood flow.
Québec, QuebecAges 20–99 - NCT07420907Recruiting
Tracking heart health over time
This study uses a wearable patch to monitor heart-related signs in people with heart conditions. It aims to learn more about how these conditions progress, which could help improve future care.
Chicago, IllinoisAges 18 years+ - NCT07414342Recruiting
Study of RENATUS® valve for severe aortic stenosis
This study tests a new device called the RENATUS® Transcatheter Aortic Valve System for people with severe aortic stenosis. It is designed to replace the narrowed valve without open-heart surgery, and aims to see if it is safe and effective for patients with various surgical risk levels.
BeijingAges 60–100 - NCT07335900Recruiting
Studying heart healing after TAVI with FAPI-PET scan
This study uses a special type of PET scan (FAPI-PET) to see how the heart heals after a less invasive valve replacement procedure called TAVI. It aims to help doctors better understand the changes in heart tissue after treatment for aortic stenosis.
ShanghaiAges 18 years+ - NCT07278310Recruiting
Siegel Valve for Severe Aortic Stenosis (TAVR)
This study tests a new replacement valve called the Siegel, placed through a catheter in your leg (TAVR), for people with severe aortic stenosis. It aims to see if it is safe and effective for patients at low, intermediate, or high surgical risk.
Atlanta, GeorgiaAges 18 years+ - NCT07276711Recruiting
Protecting brain during TAVR with EmStop device
This trial tests a new device (EmStop) that helps protect your brain during TAVR (a type of heart valve replacement). The device is placed in arteries to catch any debris that might break loose during the procedure, potentially reducing the risk of stroke.
Thousand Oaks, CaliforniaAges 22 years+ - NCT07145463Recruiting
New delivery system for severe aortic stenosis treatment
This trial tests a new delivery system (VitaFlow Liberty Flex) for placing a replacement aortic valve in people with severe aortic stenosis. It is designed for patients whose heart anatomy (a steep angle between the heart and aorta) makes the procedure more challenging.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07144189Recruiting
AI helps diagnose low-gradient aortic stenosis
This trial is testing whether an artificial intelligence (AI) program can better identify low-gradient aortic stenosis, a type of heart valve narrowing, by looking at your echocardiogram (heart ultrasound). It aims to help doctors diagnose this condition more accurately without any extra procedures.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07097740Recruiting
Study of a new polymer heart valve for mitral or aortic replacement
This study tests a new type of prosthetic heart valve made from a special polymer material. It is for adults who need surgical replacement of either the mitral or aortic valve.
Shanghai, Shanghai MunicipalityAges 50 years+ - NCT07052071Recruiting
TAVI's effect on gut bacteria in aortic stenosis
This study looks at how a heart valve procedure called TAVI affects the bacteria in your gut. It may help doctors understand how the procedure impacts your overall health.
AthensAges Any age - NCT06898086Enrolling by invitation
TAVI with or without heart artery check for severe aortic stenosis
This trial compares two approaches for replacing a tight aortic heart valve (TAVI) through a leg artery: doing it with or without a routine check of your heart's arteries (coronary angiogram). If you have severe aortic stenosis and are scheduled for TAVI, this study helps find out whether skipping the artery check is safe and effective.
GrazAges 18 years+ - NCT06679517Enrolling by invitation
Long-term follow-up for severe aortic stenosis patients considered for TAVI
This study follows patients with severe aortic stenosis (a heart valve condition) who are being evaluated for a keyhole procedure called TAVI. It aims to understand their long-term outcomes after the standard evaluation process.
FerraraAges 18 years+ - NCT06638268Recruiting
TAVI for severe aortic stenosis in cardiogenic shock
This study tests whether a procedure called TAVI (a valve replacement done through a tube in the leg) can help people with severe aortic stenosis who are in cardiogenic shock, a dangerous condition where the heart can't pump enough blood. The goal is to see if urgent valve replacement improves survival.
Copenhagen OAges Any age
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Aortic Stenosis trials by city
Studies with a site in or near these metro areas.
Aortic Stenosis trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for aortic stenosis?
- Yes. Clin2 currently lists 198 recruiting aortic stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.