Methadone for knee replacement pain and less opioids
Treatments studied
Part of Pain clinical trials.
This trial tests if adding methadone during knee replacement surgery can better control pain after the operation and reduce the need for opioid painkillers. It may help you recover with less discomfort and fewer side effects from strong pain medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You are scheduled for a first-time total knee replacement (not a revision).
- Your anesthesia plan includes a spinal injection with mepivacaine.
- You do not have severe liver disease (Child's Pugh Class C).
- You do not have end-stage kidney disease requiring dialysis.
- You do not have a known condition called prolonged QT syndrome (a heart rhythm issue).
- You are not currently pregnant.
- You can provide written consent and speak English.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a single dose of methadone given during hip replacement surgery can better control pain and reduce the need for other opioid painkillers afterward. It may help you recover with less pain and fewer side effects.
This study tests whether giving methadone during and after major spine surgery can help reduce the need for other opioid pain medicines later. It is for adults having multilevel fusion in the lower or mid-back.
This study tests whether methadone, a type of pain medicine, helps control pain better after knee replacement surgery. It is for people who have not used narcotics recently and are otherwise healthy.
This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
This trial tests if taking methadone pills after arthroscopic knee or hip surgery can help manage pain effectively. It's for people who are otherwise healthy and ready for surgery.
This trial tests whether methadone—a strong pain medication—helps manage pain better after intermediate-complexity surgery. If it works, it could reduce pain and the need for other opioids after your operation.
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