Methadone for pain relief after hip replacement surgery
Treatments studied
Part of Pain clinical trials.
This study tests whether a single dose of methadone given during hip replacement surgery can better control pain and reduce the need for other opioid painkillers afterward. It may help you recover with less pain and fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You are scheduled for a planned hip replacement surgery.
- You will receive spinal anesthesia with a medicine called mepivacaine.
- You are not allergic to methadone or mepivacaine.
- You do not have severe liver disease or end-stage kidney disease needing dialysis.
- You do not have a heart rhythm condition called prolonged QT syndrome and are not pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
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