Clot-buster procedure for blocked neck artery stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial studies whether an emergency clot-removal procedure through the blood vessels (endovascular treatment) helps people who have a stroke caused by a blocked internal carotid artery in the neck. It compares outcomes in patients treated urgently when imaging shows the blockage is likely the main cause.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18 or older.
- Have signs of an acute ischemic stroke, diagnosed by CT or MRI (or imaging that looks normal but the team still strongly suspects stroke).
- Have significant symptoms at enrollment (NIHSS score over 5) or symptoms that are worsening or coming back within the last 7 days.
- Have a specific artery problem on scan: a complete blockage of the neck internal carotid artery (cervical isolated ICA occlusion) seen on CTA or MRA, with no large blockage inside the brain on the same side.
- Be able to start the procedure within 60 minutes after enrollment, and have been well enough before the stroke (mRS 2 or less).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 3 trial studies whether removing a clot using a catheter (endovascular thrombectomy) works better for certain types of acute ischemic stroke. It focuses on people with a blocked neck artery plus a blockage in the brain, and who can’t get or didn’t respond to IV clot-busting medicine.
This trial compares a procedure to remove the blockage (endovascular therapy) with the best medications alone for people who have a mild stroke caused by a large blocked artery in the brain. The goal is to see if the procedure can improve recovery better than medicine alone.
This trial tests if removing a large blood clot from the brain up to 3 days after a stroke improves recovery compared to standard medical care alone. It is for patients who have a severe stroke and are otherwise healthy enough for the procedure.
This trial tests whether giving a clot-dissolving medication directly into the brain's blood vessels during a standard procedure (mechanical thrombectomy) can improve outcomes for people with a stroke caused by a blockage in a medium-sized artery. It may be an option for patients who arrive at the hospital within 24 hours of symptom onset and have enough salvageable brain tissue.
This trial compares two ways of removing a blood clot from a large artery in the brain during an ischemic stroke. It might help you by finding out which method restores blood flow more safely and effectively.
This study tests a rescue treatment for people having a major stroke caused by a blocked artery in the brain that also has severe narrowing. If doctors can't fully open the artery with standard clot removal, this study looks at whether additional treatments can help.
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