Vaccine study for high-risk smoldering or myeloma
Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.
This Phase 1/2 trial tests a cancer vaccine (TG01/QS-21) in people with high-risk smoldering multiple myeloma or multiple myeloma. It aims to see how safe the vaccine is and whether it can help the immune system control the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be age 18 or older and able to sign informed consent.
- Your test must show a specific RAS gene change (KRAS or NRAS at codon 12 or 13).
- You must have either high-risk smoldering multiple myeloma (SMM) or multiple myeloma (MM) with measurable disease.
- For high-risk SMM, your screening blood/bone-marrow results must meet at least 2 of these: high M-protein, a high light-chain ratio, and/or high bone-marrow plasma cells.
- If you had a stem cell transplant, you must be at least 3 months past it and have tried lenalidomide maintenance for at least 2 cycles (in certain situations).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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