Clin2
NCT05859217Possibly a fitNot yet recruiting

Cabozantinib and atezolizumab for advanced lung cancer

Lung CancerNSCLC Stage IVMetastatic NSCLC - Non-Small Cell Lung CancerAdvanced NSCLC

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This trial is testing a combination of two drugs, cabozantinib and atezolizumab, for people with advanced lung cancer that has low PD-L1 levels. The goal is to see if this combination can shrink tumors and help control the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
40 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have advanced or metastatic non-small cell lung cancer that has low levels of a protein called PD-L1 (less than 1%).
  • If you have specific genetic changes in the tumor, you must have already tried and not responded to targeted therapy for those changes.
  • You have not received any prior cancer therapy, or only targeted therapy if you had a genetic change and it stopped working.
  • You are able to perform daily activities with some help (ECOG 0-1).
  • You have a tumor sample available for research.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04467723Recruiting· Phase 1/Phase 2
Atezolizumab plus pirfenidone for advanced lung cancer

This Phase 1/2 trial tests whether combining atezolizumab and pirfenidone can help people with non-small cell lung cancer (NSCLC) after prior treatment. It is aimed at patients whose cancer has certain genetic markers ruled out and who can safely take study medicines and follow frequent visits.

Fairway, Kansas
NCT07625644Recruiting· Phase 3
New immunotherapy combination for advanced lung cancer

This trial tests a new drug called BL-M14D1 combined with atezolizumab (an immunotherapy) against standard chemotherapy for extensive-stage small cell lung cancer, a serious type of lung cancer that has spread. The goal is to see if this combination helps patients live longer and control their cancer better.

Springdale, Arkansas
NCT06356675Not yet recruiting· Phase 4
Combination therapy for advanced lung cancer after immunotherapy

This trial tests a combination of two drugs, tislelizumab and anlotinib, for people with advanced non-small cell lung cancer that has progressed after initial immunotherapy. The goal is to see if this new combination can help control the cancer.

NCT04273061Recruiting· Phase 2
Atezolizumab for tumors that look sensitive on DNA/RNA testing

This Phase 2 study tests atezolizumab, an immunotherapy drug, in people with advanced, incurable solid tumors whose tumor DNA/RNA suggests they may respond. The goal is to see if the treatment works better for patients selected by these lab results.

Vancouver, British Columbia
NCT01639508Recruiting· Phase 2
Cabozantinib for lung cancer with specific gene changes

This trial studies how well cabozantinib works in advanced lung cancer when the tumor has certain gene changes (like RET, ROS1, NTRK, MET, or AXL). It may help slow tumor growth after standard treatments, depending on your tumor test results.

Basking Ridge, New Jersey
NCT05168163Recruiting· Phase 2
Atezolizumab plus targeted drug for advanced liver cancer

This Phase 2 study tests whether atezolizumab combined with a multi-targeted (“multi-kinase”) inhibitor can treat advanced liver cancer that cannot be cured with surgery or local procedures. It focuses on people whose cancer has already grown despite a first-line treatment using atezolizumab plus bevacizumab.

Scottsdale, Arizona

Hear when a new Lung cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.