Smaller surgery after chemotherapy for recurring nasopharyngeal cancer
Treatments studied
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This trial tests whether doing a smaller surgery (after chemotherapy works well) can control recurring nasopharyngeal cancer while reducing treatment burden. It is for people whose cancer can be removed by surgery and who respond to an initial course of chemotherapy plus immunotherapy (or another targeted regimen).
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your cancer came back more than 6 months after you finished radiation therapy.
- You have a confirmed recurrence of nasopharyngeal cancer (confirmed by biopsy).
- Your tumor is in a surgical area that doctors believe can be removed (and not spread to certain critical nearby areas).
- You completed 3 cycles of induction chemotherapy plus immunotherapy (or a specific alternative regimen), and your scans showed at least partial response, with tumor size reduction greater than 50%.
- You are well enough for treatment (Karnofsky Performance Status above 70) and can sign consent and attend follow-up visits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two approaches for people with early-stage nasopharyngeal cancer that can be removed with surgery. It tests whether giving less intense chemotherapy and radiation after surgery works as well as a standard dose, with fewer side effects.
This trial tests giving chemotherapy before and after surgery for people whose nasal cancer has come back. The goal is to see if this approach helps remove the cancer more effectively and prevents it from returning again.
This trial compares two treatment plans for newly diagnosed, operable nasopharyngeal cancer: adding surgery plus targeted chemoradiation versus standard chemoradiation alone. It aims to see whether the surgery-based plan improves control of the cancer and related outcomes.
This trial tests whether a lower dose of radiation, with or without additional chemo-immunotherapy, works as well as the standard full-dose chemoradiation for people with advanced nasopharyngeal cancer who had a complete response after initial chemo-immunotherapy.
This trial compares two treatments for newly diagnosed Stage I nasopharyngeal cancer: surgery alone versus surgery followed by a lower dose of radiation. The goal is to see if adding a gentler radiation dose can prevent the cancer from coming back without too many side effects.
This trial compares two treatments for stage I nasopharyngeal cancer (a type of nasal cancer). It tests whether a minimally invasive surgery (endoscopic surgery) is as good as or better than radiation therapy. It may be an option for people whose cancer is small and hasn't spread to lymph nodes.
Hear when a new Nasopharyngeal Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.