Donor cornea treatment for advanced keratoconus
Part of Eyes & vision clinical trials.
This trial uses donated corneal tissue that was treated with a special light and riboflavin (collagen cross-linking) to strengthen it before transplant. The goal is to improve vision in people with severe keratoconus, a condition where the cornea bulges into a cone shape and gets very thin.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- Your vision must be very poor even with glasses or contact lenses, or you cannot tolerate wearing contact lenses.
- The front surface of your eye (cornea) must be too steep or too thin—your doctor can check this.
- You must be willing to come back for check-ups for 3 years (36 months) after surgery.
- You cannot have had any previous eye surgery, severe dry eye, or severe scarring of the eyelids or eye surface.
- You must have useful vision in your other eye, and if you are pregnant or breastfeeding, you cannot join.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study follows people with or at risk for keratoonus, a condition where the cornea thins and bulges. It aims to improve early detection and understand how the disease progresses.
This study tests whether treating donor corneal tissue with a special light and vitamin drops (called cross-linking) before a transplant helps improve outcomes for people with keratoconus. If you need a corneal transplant, this could strengthen the donor tissue and potentially reduce the need for future procedures.
This trial tests a new combined treatment for keratoconus that includes both a surface laser (phototherapeutic keratectomy) and corneal collagen crosslinking (CXL). It may help strengthen your cornea and improve vision.
This trial tests two different laser-based procedures to treat keratoconus, a condition that weakens and bulges the cornea. The goal is to see which approach better strengthens the eye and improves vision.
This trial studies collagen cross-linking, a procedure meant to strengthen a weakened cornea in people with keratoconus. It may help slow the bulging/weakening of the cornea and improve vision, and the study also uses special imaging to check changes over time.
This study tests a procedure called Xenia corneal lenticule in people with severe keratoconus or severe post-LASIK corneal thinning who want to avoid a corneal transplant. It aims to improve vision while checking safety and how well the new procedure works over time.
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