Clinical trials
Keratoconus clinical trials
Below are recruiting keratoconus clinical trials, each written for real people, not researchers. We’re tracking 36 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06451718Recruiting
A new implant for keratoconus to avoid corneal transplant
This trial tests a small metal implant placed in the cornea to treat keratoconus, a condition where the cornea thins and bulges. The goal is to see if the implant can safely improve vision and prevent the need for a corneal transplant.
Roma, RomaAges 18 years+ - NCT04598932Enrolling by invitation
Eye pressure and tissue testing for cornea health
This study uses a special, noninvasive microscope technique to study how your cornea tissue behaves. It may help doctors better understand keratoconus and corneal changes after common eye procedures.
Cleveland, OhioAges 18–60 - NCT04591587Enrolling by invitation
Corneal lenticule implant for keratoconus
This trial tests a new surgical procedure using a small piece of corneal tissue (a lenticule) from a donor to strengthen the cornea in people with progressive keratoconus. The goal is to help stop the disease from getting worse.
PristinaAges 20–40 - NCT06264024Recruiting
Combined laser and crosslinking for keratoconus
This trial tests a new combined treatment for keratoconus that includes both a surface laser (phototherapeutic keratectomy) and corneal collagen crosslinking (CXL). It may help strengthen your cornea and improve vision.
OsloAges 18 years+ - NCT07841470RecruitingPhase 2/Phase 3
Corneal crosslinking for progressive keratoconus or corneal ectasia
This study tests a procedure called corneal crosslinking to slow or stop the progression of keratoconus or corneal ectasia. It might help keep your cornea stable and prevent further vision loss.
Indianapolis, IndianaAges 10–90 - NCT07629557RecruitingPhase 4
Same-Day Corneal Cross-Linking for Keratoconus in Both Eyes
This study tests a same-day procedure that strengthens the cornea (the clear front part of the eye) in both eyes using a special light treatment, called cross-linking. It may help slow or stop the progression of keratoconus, a condition where the cornea becomes cone-shaped and causes blurry vision.
Westerville, OhioAges 13 years+ - NCT06722937Recruiting
Collagen factors in fast-progressing keratoconus in kids
This study looks at why keratoconus gets worse quickly in children. You may help doctors understand how collagen affects the condition.
Guangzhou, GuangdongAges 10–50 - NCT07559188Recruiting
A contact lens for presbyopia and keratoconus
This trial tests a special contact lens that uses a tiny opening to improve vision for people with presbyopia (age-related reading blur) or with keratoconus (a cone-shaped cornea). The lens aims to make both near and distant objects clearer without surgery.
AntwerpAges 18 years+ - NCT06601101RecruitingPhase 3
Insulin drops for faster healing after corneal crosslinking
This trial tests whether insulin eye drops can help the cornea heal faster after corneal crosslinking, a procedure to treat keratoconus. It is for people with keratoconus who do not have diabetes, severe dry eye, or certain other eye conditions.
Campinas, São PauloAges 14 years+ - NCT07400952RecruitingPhase 2
Testing GLK-221 Eye Drops for Keratoconus
This study tests an eye drop called GLK-221 for people with keratoconus, a condition where the clear front of the eye bulges. The goal is to see if the drops can safely help improve the condition compared to a placebo (an inactive solution).
Westerville, OhioAges 18–55 - NCT07388069Enrolling by invitationPhase 1/Phase 2
TN-001 eyedrops for progressive keratoconus
This trial tests a new eyedrop (TN-001) for people with keratoconus that is getting worse. The drops are applied twice a day to try to stop the cornea from thinning and bulging further.
Brisbane, QueenslandAges 18–40 - NCT07372911Recruiting
Comparing two cornea treatments for keratoconus
This trial tests two different laser-based procedures to treat keratoconus, a condition that weakens and bulges the cornea. The goal is to see which approach better strengthens the eye and improves vision.
Mexico City, Mexico CityAges 18 years+ - NCT06450470RecruitingPhase 3
Amniotic membrane after crosslinking for progressive keratoconus
This trial tests if placing a special freeze-dried amniotic membrane on the eye after crosslinking surgery helps improve healing and comfort for people with progressive keratoconus, a condition where the cornea thins and bulges.
BrestAges 18–65 - NCT07135167RecruitingPhase 3
Epi-ON corneal crosslinking study for people with Down syndrome
This study tests a special light treatment for cornea problems in people with Down syndrome. It aims to strengthen the front of the eye and may help prevent vision loss.
Atlanta, GeorgiaAges 8 years+ - NCT07124910RecruitingPhase 3
Comparing two UV light times for corneal crosslinking
This trial tests two different UV light exposure times (18 minutes vs. 24 minutes) during a corneal crosslinking procedure for people with keratoconus or similar corneal thinning conditions. The goal is to see if the shorter time works as well as the longer one.
Atlanta, GeorgiaAges 8 years+ - NCT07096232Enrolling by invitation
AI vs doctor for eye surgery and keratoconus diagnosis
This study compares an AI system to a specialist eye doctor to see which is better at diagnosing vision problems like nearsightedness, farsightedness, astigmatism, and keratoconus. Your existing medical records will be used to see how well the AI performs.
Cairo, MaadiAges Any age - NCT06921967Recruiting
Rigid contact lenses for keratoconus
This study tests how well rigid gas permeable (RGP) contact lenses work for people with keratoconus, a condition where the cornea becomes cone-shaped. It looks at eye health and vision quality.
AarhusAges 18–40 - NCT05676580Recruiting
Study of risk factors and vision changes in keratoconus
This study looks at what leads to keratoconus and how it progresses over time. It may help doctors better predict worsening vision and plan earlier care.
Montpellier, OccitanieAges 10–40 - NCT03760432Recruiting
Cornea strengthening study for keratoconus using collagen cross-linking
This trial studies collagen cross-linking, a procedure meant to strengthen a weakened cornea in people with keratoconus. It may help slow the bulging/weakening of the cornea and improve vision, and the study also uses special imaging to check changes over time.
Portland, OregonAges 18 years+ - NCT04439552Recruiting
MRI study during cornea cross-linking for keratoconus
This trial uses an MRI scan (and a close-up eye scan) to study what happens in the cornea during treatment for keratoconus. It may help doctors better understand how treatment works and who benefits most.
Boston, MassachusettsAges 8–35 - NCT03923101Recruiting
Study for people with keratoconus at a specialty eye clinic
This trial is for people who have keratoconus (a cornea condition that can blur vision). It involves receiving care or evaluation at the Homburg Keratoconus Center, and it may help by improving how keratoconus patients are managed.
Homburg, SaarlandAges Any age - NCT02138669Recruiting
Prescription cornea insert for keratoconus when vision worsens
This trial tests whether prescription inserts placed in the cornea can improve day-to-day vision for people with keratoconus whose vision is getting worse and who have few options left. You may be able to avoid or delay corneal transplant depending on your cornea shape and thickness.
Dallas, TexasAges 18 years+ - NCT04251143Recruiting
Study for corneal disease and corneal thinning
This study looks at people with corneal disease, especially corneal thinning that can change how the eye focuses light. It may help researchers understand treatments and care plans for these conditions.
Dresden, SaxonyAges 18–65 - NCT05516004RecruitingPhase 2
Cornea strengthening treatment study for thinning corneas
This Phase 2 study tests whether a procedure called PXL‑Platinum 330 can safely and effectively strengthen corneas that are thinning (such as keratoconus or related conditions). It aims to see if the treatment can help stabilize or improve the cornea’s shape while keeping side effects low.
Boca Raton, FloridaAges 18 years+
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Keratoconus trials by city
Studies with a site in or near these metro areas.
Keratoconus trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for keratoconus?
- Yes. Clin2 currently lists 36 recruiting keratoconus studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a keratoconus trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a keratoconus trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.