First-line treatment for left-sided metastatic colon cancer with specific tumor markers
Part of Cancer, Digestive system clinical trials.
This Phase 2 trial tests a combination of medicines (cetuximab, envafolimab, and chemotherapy) as the first treatment for certain left-sided metastatic colorectal cancers. It may help by slowing or shrinking the cancer in people whose tumor has no RAS/BRAF mutations and is microsatellite-stable (MSS).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and able to understand and sign the consent form.
- Your colon cancer has been confirmed by a lab test as left-sided, stage IV, and metastatic.
- Your tumor test shows RAS and BRAF are wild-type, and it is MSS; you cannot have appendiceal or anal cancer.
- You have not had any prior treatment for advanced/metastatic colon cancer (no prior chemo for that purpose, no EGFR antibodies like cetuximab/panitumumab, no bevacizumab, and no immune checkpoint therapy like anti–PD-1/PD-L1 or anti–CTLA-4).
- Your health status is good enough for treatment (ECOG performance status 0 or 1), and recent blood/organ tests meet required limits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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