Cetuximab plus irinotecan for left-sided RAS/BRAF wild-type colon cancer
Part of Cancer, Digestive system clinical trials.
This Phase 2 trial tests whether adding cetuximab to irinotecan can control metastatic colorectal cancer that has returned or worsened after standard treatments. It targets people whose tumor is left-sided and shows “wild-type” RAS and BRAF genes on blood testing after prior therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older.
- You have colorectal adenocarcinoma (colon/rectal cancer) that has spread (metastatic).
- Your cancer is left-sided (right-sided cancers are not eligible).
- Your cancer has “wild-type” RAS and BRAF genes on blood test after your second treatment progression.
- Your cancer got worse within 3 months during or after an irinotecan-containing treatment.
- Your overall health tests are good enough for treatment (blood counts, liver/kidney function, and heart status), and your performance status is 0 to 2.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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