Short-course radiation plus chemo before surgery for advanced rectal cancer
Part of Cancer, Digestive system clinical trials.
This study tests a new approach: using short-course radiation followed by a combination of chemotherapy (called TNT) before surgery for advanced rectal cancer that hasn't spread. The goal is to shrink the tumor and possibly avoid permanent colostomy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Between 18 and 70 years old
- Adenocarcinoma (a common type) of the rectum confirmed by biopsy
- The tumor is within about 4 inches (10 cm) of the anus
- No prior cancer treatment for this disease
- Cancer is stage cT4 (locally advanced) but has not spread to distant organs
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new approach for people with locally advanced rectal cancer that has high-risk features. It combines short-course radiation with chemotherapy (CapeOX) and the immunotherapy drug toripalimab, with or without another drug called surufatinib, before surgery. The goal is to see if adding these drugs helps shrink the tumor and improve outcomes.
This trial tests a combination of short-course radiation, chemotherapy (CapeOx), and an immunotherapy drug (PD-1 inhibitor) for people with early-stage rectal cancer who have had a local excision but are at high risk of the cancer coming back. The goal is to avoid more extensive surgery while still effectively treating the cancer.
This trial compares two chemotherapy plans given before rectal cancer surgery to see which helps more people and works better for disease control. If you have locally advanced rectal cancer and have not had treatment yet, this study may be an option.
This trial tests a short course of radiation given before chemotherapy for people with locally advanced rectal cancer (cancer that has grown into nearby tissue and/or nearby lymph nodes but can still be removed). It may help shrink the tumor and make treatment more effective while assessing how well this approach works.
This trial tests two new drugs (fruquintinib and tislelizumab) plus standard chemo before surgery for rectal cancer that has not spread. The goal is to see if this combination works better than standard chemo alone.
This trial tests a combination of chemotherapy and radiation therapy before surgery for people with mid or low rectal cancer that hasn't spread. The goal is to see if this approach works better than current treatments.
Hear when a new Rectal Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.