LOT-CRT vs standard CRT for heart failure with NICD
Part of Heart & circulation clinical trials.
This study compares a newer pacing therapy (LOT-CRT) to standard cardiac resynchronization therapy (BiVP) for people with heart failure who have a specific type of electrical delay in the heart (NICD). The goal is to see if the newer method works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a weakened heart muscle (cardiomyopathy), either from blocked arteries or other causes.
- You are already on the best heart failure medications for at least 3 months.
- Your heart failure symptoms limit your daily life (NYHA class II, III, or IV).
- Your heart's pumping ability (ejection fraction) is 35% or less.
- You have a normal heart rhythm (sinus) with a very wide QRS (≥150ms) that is not a typical left or right bundle branch block.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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