Knee injections for osteoarthritis: comparing three options
Part of Bones, joints & muscles, Pain clinical trials.
This study compares three types of knee injections for knee arthritis to see which gives the best pain relief: platelet-rich plasma (PRP) made from your own blood, a special fat-derived cell treatment (MFAT), or a combination. If you have persistent knee pain, this could help you find a treatment that works better than standard options.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 20 and 75 years old.
- You have ongoing knee pain (rated higher than 4 out of 10) from wear-and-tear or an old injury, and typical treatments like physical therapy, painkillers, or knee injections have not helped after at least a year.
- Your knee is not severely bowed or knocked (less than 5 degrees of varus or valgus).
- You have a normal or above-normal body weight (BMI over 20) so there is enough fat tissue for the procedure.
- You must be free of conditions that prevent an MRI, such as a pacemaker or metal fragments in the eye.
- You are not taking blood-thinning drugs (like aspirin) for at least 15 days before the procedure, and you have no active infections, blood disorders, or recent cancer history.
- If you are of childbearing age, you must have a negative pregnancy test and use contraception for at least a month.
- You must be covered by French social security (or equivalent) and not be under legal guardianship or in an institution.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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