Study of Append system for atrial fibrillation patients
Part of Heart & circulation clinical trials.
This trial tests a new device, the Append System, to close off the left atrial appendage (a small pouch in the heart) in people with atrial fibrillation. The goal is to reduce stroke risk without needing long-term blood thinners.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have atrial fibrillation (AF), a type of irregular heartbeat that is not caused by a reversible issue like thyroid problems or recent surgery.
- Your stroke risk score (CHA2DS2-VASc) is at least 2 for men or 3 for women, and you are not already on blood thinners for other reasons besides AF.
- You have not had a recent stroke, TIA (mini-stroke), or heart attack within the last 3 months, and no major heart or other surgery within the last 30 days.
- You are willing to take a specific combination of blood thinners and aspirin after the procedure.
- You have no serious health problems such as severe heart failure, kidney failure (dialysis), active infection, or conditions that would prevent safe imaging or anesthesia.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether closing a heart pocket called the left atrial appendage can lower future stroke or other clot-related events in people with atrial fibrillation. It’s mainly for people who have had a prior clot-related event or are at higher risk but may not be good candidates for long-term blood thinners.
This trial tests a device called LAmbre™ II that is placed in the heart to reduce stroke risk in people with atrial fibrillation who cannot take blood thinners. It may be an option if you need an alternative to long-term blood-thinning medication.
This trial tests a new device called ENDOMATIC SEPIOLA that closes a small pouch in your heart (the left atrial appendage) to lower your stroke risk. It is a non-surgical option for people with atrial fibrillation who cannot take blood thinners.
This trial tests a procedure that closes off a small pouch in the heart (left atrial appendage) while also treating irregular heartbeat (atrial fibrillation) with a catheter ablation procedure. The goal is to reduce your stroke risk and treat your symptoms without needing blood thinners long-term.
This study tracks patients who have a minimally invasive procedure to close off a small pouch in the heart called the left atrial appendage. The procedure aims to reduce stroke risk, and this registry collects information about how patients do after the procedure.
This trial compares two different devices (Amplatzer Amulet and LAmbre) used to close a small pouch in the heart called the left atrial appendage. People with atrial fibrillation who are at high risk for stroke and bleeding may be able to stop blood thinners after the procedure.
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