Study of Append system for atrial fibrillation patients
Part of Heart & circulation clinical trials.
This trial tests a new device, the Append System, to close off the left atrial appendage (a small pouch in the heart) in people with atrial fibrillation. The goal is to reduce stroke risk without needing long-term blood thinners.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have atrial fibrillation (AF), a type of irregular heartbeat that is not caused by a reversible issue like thyroid problems or recent surgery.
- Your stroke risk score (CHA2DS2-VASc) is at least 2 for men or 3 for women, and you are not already on blood thinners for other reasons besides AF.
- You have not had a recent stroke, TIA (mini-stroke), or heart attack within the last 3 months, and no major heart or other surgery within the last 30 days.
- You are willing to take a specific combination of blood thinners and aspirin after the procedure.
- You have no serious health problems such as severe heart failure, kidney failure (dialysis), active infection, or conditions that would prevent safe imaging or anesthesia.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a device and procedure to close off a small pouch in the heart (left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke, possibly lowering the need for long-term blood thinners.
This study tests whether closing a heart pocket called the left atrial appendage can lower future stroke or other clot-related events in people with atrial fibrillation. It’s mainly for people who have had a prior clot-related event or are at higher risk but may not be good candidates for long-term blood thinners.
This trial tests a procedure to close off a small pouch in the heart called the left atrial appendage, which is a common source of blood clots in people with atrial fibrillation. The goal is to lower your stroke risk without needing to take blood thinners long-term.
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