Donor islet transplant for brittle type 1 diabetes
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This study tests a one-time transplant of insulin-making cells from a donor to treat brittle type 1 diabetes—a condition where blood sugar swings wildly and dangerously low. The goal is to help people who still have severe low blood sugar episodes despite intensive insulin therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 6 and 65 years old.
- You have had type 1 diabetes for at least one year and still have trouble controlling your blood sugar with insulin (A1C 7.5% or higher, or time in range less than 70%).
- You have had two or more severe low blood sugar episodes in the past year, with at least one in the last three months.
- Your body makes diabetes-related antibodies (like GAD or insulin autoantibodies) that show it's type 1 diabetes.
- You are willing to use study-provided blood sugar monitoring tools, keep a log, and use reliable birth control (if able to become pregnant or father a child).
- You do not have active infections, untreated cancer, severe organ problems, or other conditions that would prevent you from safely taking the trial medication or immunosuppressants.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether transplanting your own insulin-making cells (islets) can help control blood sugar if you have type 2 diabetes and your pancreas is not making enough insulin. The goal is to reduce or stop your need for insulin injections.
This study tests a new treatment called E-islet 01, which may help people with type 1 diabetes who have very low natural insulin production and have had dangerous low blood sugar events. The goal is to see if it is safe and can reduce those episodes.
This trial tests a two-step transplant approach using immune-related stem cells and islet (pancreas insulin–making) cells in children and teens who have type 1 diabetes caused by a genetic immune problem. It aims to improve insulin control and protect other organs that are being affected by their immune system.
This trial tests if umbilical cord stem cells can improve the success of islet cell transplants for people with diabetes whose own pancreas no longer makes enough insulin. It aims to help patients achieve better blood sugar control and reduce dangerous low blood sugar episodes.
This trial tests whether lab-grown islet cells (pancreatic organoids) can help control blood sugar in people who develop diabetes after having most or all of their pancreas removed. If successful, this could reduce the need for insulin shots.
This trial studies whether transplanting insulin-producing islet cells can improve blood sugar control and reduce severe low blood sugar in people with “brittle” type 1 diabetes. It’s meant for adults with long-standing insulin dependence and troublesome, hard-to-control hypoglycemia.
Hear when a new Brittle Type 1 Diabetes Mellitus trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.