Islet transplant study for adults with type 1 diabetes
Part of Hormones & metabolism clinical trials.
This early study tests a new kind of donor islet transplant (UP421) designed to avoid rejection. It's for adults with long-standing type 1 diabetes who have trouble controlling blood sugar despite intensive insulin therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have type 1 diabetes, diagnosed before age 18 and for at least 5 years.
- You are between 30 and 45 years old and weigh less than 80 kg (about 176 lbs).
- You manage your diabetes intensively – at least 3 insulin shots daily (or a pump) and check blood sugar at least 3 times a day.
- Your HbA1c (average blood sugar over 3 months) is 8.6% or higher.
- Your body makes very little to no C-peptide (meaning your pancreas doesn't produce much insulin).
- You are willing to use effective birth control (if needed) and not plan pregnancy for at least 1 year after the transplant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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