Bevacizumab for adults with symptomatic, untreatable brain AVMs
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This trial tests a medication called bevacizumab (given as an IV infusion) to see if it can improve symptoms in people with brain arteriovenous malformations (AVMs) that cannot be treated with standard therapies. It is for those whose AVMs cause significant disability.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have a symptomatic brain AVM that is large or complex (grades III, IV, or V) and causing problems like headaches, seizures, thinking issues, or weakness.
- Your symptoms are significant enough to show improvement, as measured by certain tests or scores.
- Your symptoms are not just from a past brain bleed and are disabling in daily life.
- You have been told that standard treatments (surgery, embolization, or radiation) are not an option for you.
- You have normal bone marrow, liver, and kidney function (checked by blood tests).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks for blood test markers that may predict who survives at 6 months after starting bevacizumab for glioblastoma that has come back. It does not aim to cure the cancer by itself, but to improve doctors’ ability to choose the most helpful treatment plan.
This trial uses a blood test to look for genetic mutations in brain arteriovenous malformations (bAVMs). It may help doctors understand these lesions better and guide treatment.
This trial tests a drug injected directly into the brain's abnormal blood vessels to see if it can help people who can't have surgery or other standard treatments. It may reduce symptoms and prevent future bleeding.
This early-stage trial tests whether giving a targeted cancer medicine (bevacizumab) directly into brain arteries can help shrink or control certain recurrent (coming back) brain tumors. It may be an option if standard treatments are no longer working.
This trial tests whether giving bevacizumab (a drug that blocks blood vessel growth) before surgery helps treat newly diagnosed high-grade gliomas. It may be an option for adults who have not had prior anti-angiogenic therapy.
This trial tests an oral medication called FCN-159 for people with a high-grade brain AVM that has never bled. The goal is to see if it can shrink the AVM or prevent future problems.
Hear when a new Cerebral AV Malformation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.