Using ATG to prevent graft-versus-host disease after stem cell transplant
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests if a two-step course of a drug called ATG (anti-thymocyte globulin) can help prevent a serious side effect called graft-versus-host disease (GVHD) after a donor stem cell transplant. It is for people with certain blood cancers who are receiving a reduced-intensity transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have a related or unrelated stem cell donor who is a good match.
- You are getting a reduced-intensity transplant because of age (60+), health issues, or higher risk of side effects from a stronger regimen.
- Your heart, kidney, lung, and liver functions meet minimum health levels.
- You have a diagnosis of AML, MDS, or myelofibrosis with specific features like certain genetic changes or blast cells in the marrow or blood.
- You have not had a previous donor stem cell transplant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a two-step use of ATG (a drug that calms immune cells) to help prevent graft-versus-host disease (GVHD) in patients receiving a stem cell transplant from a donor. It may be an option for people with certain blood cancers or disorders who are getting a strong, marrow-clearing transplant.
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