Lowered immune drug plus mini transplant method for preventing graft vs host disease
Part of Blood & lymphatic clinical trials.
This trial tests a new combination of medicines to prevent graft-versus-host disease (GVHD) in patients with leukemia or myelodysplastic syndromes receiving a stem cell transplant from a half-matched donor. It aims to see if using less anti-thymocyte globulin (ATG) plus a simpler post-transplant cyclophosphamide (PTCy) regimen works as well as standard care with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have leukemia in remission or myelodysplastic syndromes and are getting your first stem cell transplant
- You are between 12 and 65 years old
- Your transplant donor is a half-matched family member (like a parent, child, or sibling) who is not your mother or a collateral relative
- You are able to do most daily activities (performance status score 3 or less)
- Your heart pumps well (LVEF > 55%) and your kidneys work fine (creatinine not too high)
- You do not have active cancer that is not responding to treatment, or other cancers being treated
- You do not have a severe active infection or a history of serious allergic reactions
- You are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if a two-step course of a drug called ATG (anti-thymocyte globulin) can help prevent a serious side effect called graft-versus-host disease (GVHD) after a donor stem cell transplant. It is for people with certain blood cancers who are receiving a reduced-intensity transplant.
This trial tests a two-step use of ATG (a drug that calms immune cells) to help prevent graft-versus-host disease (GVHD) in patients receiving a stem cell transplant from a donor. It may be an option for people with certain blood cancers or disorders who are getting a strong, marrow-clearing transplant.
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