Clinical trials
Leptomeningeal Metastasis clinical trials
Below are recruiting leptomeningeal metastasis clinical trials, each written for real people, not researchers. We’re tracking 30 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07263425RecruitingPhase 2
Study of thiotepa and trastuzumab for breast cancer that spread to the lining of the brain and spinal cord
This trial tests a combination of two drugs given through a special port in the head to treat HER2-positive breast cancer that has spread to the layer covering the brain and spinal cord (leptomeningeal metastasis). It aims to see if this treatment is safe and effective.
Nanjing, JiangsuAges 18–75 - NCT06543992RecruitingPhase 2
Chemotherapy for breast cancer that spread to the brain lining
This trial tests a combination of two chemotherapy drugs (thiotepa and methotrexate) given directly into the fluid around your brain and spine through a small implanted device. It aims to treat breast cancer that has spread to the lining of the brain or spinal cord.
Nanjing, JiangsuAges 18–75 - NCT05746754Recruiting
Proton radiation for cancer spread into the covering of the brain
This trial tests proton radiation to treat cancer that has spread into the thin lining around the brain and/or spinal cord (leptomeningeal metastasis). It may help control disease in that area while aiming to better protect surrounding healthy tissue.
Aarhus, AarhusAges 18 years+ - NCT06417710Recruiting
Standardized check-up for leptomeningeal metastasis
This study watches and writes down how patients with cancer that has spread to the brain or spinal cord lining (leptomeningeal metastases) are doing. It helps doctors learn more about this condition without giving any new treatments.
Houston, TexasAges 18 years+ - NCT06638294Recruiting
Study for breast cancer spread to brain lining
This study is for people with breast cancer that has spread to the lining of the brain or spinal cord (called leptomeningeal metastasis). Researchers want to understand how to treat this condition and offer care to those who qualify.
Washington D.C., District of ColumbiaAges 4 months+ - NCT06809517RecruitingPhase 1/Phase 2
Study of a new antibody plus chemotherapy for leptomeningeal metastasis
This trial tests a combination treatment for cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). It uses an antibody given directly into the spinal fluid along with a chemotherapy drug, with the goal of targeting the cancer more effectively.
Huizhou, GuangdongAges 21–75 - NCT06705049Enrolling by invitation
Study on cancer spread to the lining of the brain
This study looks at how solid tumors spread to the lining of the brain and spinal cord. It aims to understand this condition better by reviewing patient records.
ShanghaiAges 18–80 - NCT05800275RecruitingPhase 2
Tucatinib and capecitabine plus spinal trastuzumab for HER2+ cancer
This Phase 2 trial tests a combination of tucatinib and capecitabine (taken by mouth) plus trastuzumab delivered into the spinal fluid, to treat breast cancer that has spread to the leptomeninges (lining around the brain/spinal cord). It may help reduce cancer activity in the spinal fluid and improve symptoms.
BordeauxAges 18 years+ - NCT06230055RecruitingPhase 4
Chemotherapy for breast cancer that has spread to the spinal fluid
This trial tests a chemotherapy drug given directly into the spinal fluid for people with HER2-negative breast cancer that has spread to the lining of the brain and spinal cord (called leptomeningeal metastasis). It may help when standard treatments have stopped working or caused too many side effects.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06643000Recruiting
High-dose furmonertinib combo for EGFR lung cancer with brain lining spread
This trial tests a strong dose of furmonertinib (a targeted pill) combined with two other drugs, bevacizumab and pemetrexed, for people with EGFR-mutated non-small cell lung cancer that has spread to the lining of the brain or spinal cord. It aims to see if this combination can better control the cancer and improve symptoms.
Zhengzhou, HenanAges 18 years+ - NCT06296745RecruitingPhase 2
Pemetrexed in spinal fluid for lung cancer that spread to brain lining
This trial tests a drug called pemetrexed, given directly into the fluid around the spinal cord (intrathecal), for people with lung cancer that has spread to the brain and spinal cord lining and is no longer controlled by the targeted therapy osimertinib.
Huizhou, GuangdongAges 18–75 - NCT07348965Recruiting
High-dose furmonertinib for EGFR-mutant lung cancer that spread to the brain lining
This trial tests a new way to give a targeted therapy (furmonertinib) to people with a specific type of lung cancer that has spread to the lining of the brain. It uses a higher, pulsing dose to try to get more medicine into the brain fluid and stop the cancer there.
Guangzhou, GuangdongAges 18–75 - NCT07751536Recruiting
Proton radiation and intrathecal chemo for lung cancer that has spread to the brain lining
This trial tests a combination of proton radiation to the brain and spine plus chemotherapy given directly into the fluid around the brain and spinal cord. It is for people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the lining of the brain and has continued to grow despite taking a third-generation TKI medicine like osimertinib.
Hefei, AnhuiAges 18–75 - NCT06304441Recruiting
Pemetrexed plus lung cancer pill for brain metastasis
This trial tests if adding an injected chemotherapy drug (pemetrexed) to a targeted oral pill (like osimertinib) works better than the pill alone for patients with lung cancer that has spread to the brain and spinal cord lining.
Huizhou, GuangdongAges 18–75 - NCT05805631RecruitingPhase 2
Pemetrexed into spinal fluid for EGFR-mutant lung cancer spread to brain lining
This Phase 2 trial tests giving pemetrexed directly into the spinal fluid to treat cancer that has spread to the brain’s and spinal cord’s lining (leptomeningeal metastasis). It is for people with EGFR-mutant non-squamous lung cancer whose disease progressed after osimertinib, and who may benefit from a targeted treatment delivered to the area affected in the brain lining.
Taipei, TaiwanAges 20 years+ - NCT05184816RecruitingPhase 1
Deferoxamine for leptomeningeal cancer spread in the brain lining
This Phase 1 study tests deferoxamine, a medicine given directly into spinal fluid, for leptomeningeal metastasis (cancer spreading to the brain and spinal cord lining). It’s meant to see whether the treatment can be safely given and whether it may help control this difficult-to-treat cancer location.
Basking Ridge, New JerseyAges 18 years+ - NCT06901817RecruitingPhase 2
Study of pemetrexed plus nivolumab for lung cancer that has spread to the lining of the brain
This trial tests a combination of two drugs, pemetrexed and nivolumab, given directly into the fluid around the brain and spinal cord. It is for people with a specific type of lung cancer (non-squamous non-small cell) that has spread to the lining of the brain and has not responded to other treatments.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07092202RecruitingPhase 4
Firmonertinib and spinal injection for EGFR lung cancer with spread to brain lining
This trial tests combining a targeted pill (firmonertinib) with medication injected into the fluid around the spine for people with a specific type of lung cancer that has spread to the lining of the brain. It may offer a new option if you have already tried other EGFR drugs and are still having progression.
Wuhan, HubeiAges 18 years+ - NCT07098806RecruitingPhase 1
Study of radioactive nanoparticles for cancer in the spinal fluid
This trial tests a radioactive nanoparticle drug given directly into the fluid around the brain and spine to treat cancer that has spread to the lining of the brain or spinal cord (leptomeningeal metastases). It aims to see if this targeted treatment is safe and might help shrink or control the cancer.
San Antonio, TexasAges 18 years+ - NCT07559097RecruitingPhase 1/Phase 2
Methotrexate-loaded vesicles injected into spine fluid for lung cancer spread to brain membranes
This study tests a new way to deliver a cancer drug directly into the fluid around your brain and spinal cord to treat lung cancer that has spread to the membranes covering the brain. It may help patients whose cancer hasn't responded to standard treatments.
Zhengzhou, HenanAges 18 years+ - NCT02422641RecruitingPhase 2
High-dose methotrexate for breast cancer in the brain lining
This Phase 2 trial tests whether giving high-dose methotrexate into the bloodstream can help treat breast cancer that has spread to the thin lining covering the brain and spinal cord. It may help reduce cancer in the leptomeningeal (brain-lining) area and control symptoms.
Baltimore, MarylandAges 18 years+ - NCT06718972Recruiting
Lung cancer with brain lining spread: real-world treatment study
This study looks at how people with non-small cell lung cancer that has spread to the lining of the brain or spinal cord are treated in real-world clinics in China. If you have received treatment for this spread since 2018, you may be able to help doctors learn what works best.
Guangzhou, GuangdongAges Any age - NCT05257967Recruiting
Testing spinal fluid in EGFR-mutant lung cancer with brain covering spread
This trial looks at spinal fluid (also called CSF) in adults with EGFR-mutant lung cancer that has spread to the lining around the brain/spinal cord. The goal is to better understand the disease and what the spinal fluid tests may show to guide care.
Vancouver, British ColumbiaAges 18 years+ - NCT06663306RecruitingPhase 1
Intrathecal pemetrexed and bevacizumab for lung cancer brain spread
This trial tests a treatment given directly into the fluid around the brain and spinal cord (intrathecal injection) using two drugs—pemetrexed and bevacizumab—for people with non-small cell lung cancer that has spread to that area (leptomeningeal metastases). It may be an option if your current treatment is no longer working.
ShanghaiAges 18 years+
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Common questions
- Are there clinical trials for leptomeningeal metastasis?
- Yes. Clin2 currently lists 30 recruiting leptomeningeal metastasis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a leptomeningeal metastasis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a leptomeningeal metastasis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.