Pemetrexed plus lung cancer pill for brain metastasis
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This trial tests if adding an injected chemotherapy drug (pemetrexed) to a targeted oral pill (like osimertinib) works better than the pill alone for patients with lung cancer that has spread to the brain and spinal cord lining.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 to 75 years old
- Have a specific type of lung cancer (NSCLC) with an EGFR mutation (L858R or Exon19Del)
- Have cancer that has spread to the brain and spinal cord lining (leptomeningeal metastasis)
- Have normal liver and kidney function and adequate blood cell counts
- No history of severe nervous system disorders
- No other rapidly spreading cancers that are not being treated
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests a drug called pemetrexed, given directly into the fluid around the spinal cord (intrathecal), for people with lung cancer that has spread to the brain and spinal cord lining and is no longer controlled by the targeted therapy osimertinib.
This study tests whether a drug called pemetrexed, given directly into the fluid around your brain through a small implanted device, is safe and effective for treating lung cancer that has spread to the lining of the brain. It is for people whose cancer has a specific genetic change (EGFR, ALK, or ROS1) and who have already tried standard targeted pills that no longer control their disease.
This Phase 2 trial tests giving pemetrexed directly into the spinal fluid to treat cancer that has spread to the brain’s and spinal cord’s lining (leptomeningeal metastasis). It is for people with EGFR-mutant non-squamous lung cancer whose disease progressed after osimertinib, and who may benefit from a targeted treatment delivered to the area affected in the brain lining.
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